Update: The National Cancer Institute is honored by the Federal Laboratory Consortium's 2016 “Excellence in Technology Transfer” Awards. Awardees discuss their award-winning collaborations in these two new videos:
NCI – Development of First Immunotherapy to Treat Chordoma, a Rare Cancer
Discovery to Commercialization: A New Immunotherapy for a Rare Childhood Cancer, Neuroblastoma
The National Cancer Institute (NCI) was the recipient of two "Excellence in Technology Transfer" awards at the Federal Laboratory Consortium (FLC) Annual Meeting in April, 2016. The award “recognizes employees of FLC member laboratories and non-laboratory staff who have accomplished outstanding work in the process of transferring federally developed technology,” explains the FLC. To learn more about why NCI received this recognition as well as the individuals behind them, see below.
“Development of First Immunotherapy to Treat Chordoma, Rare Bone Cancer”
“Development of First Immunotherapy to Treat Chordoma, a Rare Bone Cancer” was selected for exemplifying excellence in technology transfer process because of the complexity and the dedication of the team involved. To help advance NCI’s discovery of a vaccine capable of inducing a specific, targeted immune response against cancer cells expressing the brachyury protein, NCI formed collaborations with three commercial partners to develop brachyury vaccines. These collaborations led to the rapid translation of investigational therapeutic vaccines with the potential to revolutionize how researchers and physicians treat many cancers. Furthermore, the collaborations led to new intellectual property, licensing activities, and the management of several issued patents and pending patent applications. While NCI’s commitment to collaborate with multiple partners is helping to realize the discovery’s full potential, the resulting, rapid scientific process has required careful management of a complex technology transfer process. To learn more about the outcome from one of the collaborations, see: Vaccine Therapy for Unresectable Chordoma.
Mojdeh Bahar, J.D., U.S.Department of Agriculture (formerly of the NIH Office of Technology Transfer)
Kevin Brand, J.D., Center for Disease Control and Prevention (formerly of the NCI Technology Transfer Center)
Kevin W. Chang, Ph.D., NCI Technology Transfer Center
Sabarni Chatterjee, Ph.D., NCI Technology Transfer Center
James Gulley, M.D., Ph.D., Genitourinary Malignancies Branch, Center for Cancer Research, NCI
Christopher Heery, M.D., Clinical Trials Group,Laboratory of Tumor Immunology and Biology, Center for Cancer Research, NCI
Claudia Palena, Ph.D., Laboratory of Tumor Immunology and Biology, Center for Cancer Research, NCI
Michael Pollack, Ph.D., NCI Technology Transfer Center
Jeffrey Schlom, Ph.D., Laboratory of Tumor Immunology and Biology, Center for Cancer Research, NCI
Pictured left to right: Mojdeh Bahar (winner), Kevin Brand (winner); Paul Zielinski, FLC Executive Board Chair; Christopher Heery (winner); Claudia Palena (winner); Thomas Stackhouse, Ph.D., NCI; Sabarni Chatterjee (winner); Mark Reeves, FLC Vice Chair; Ana Amar, NIH Agency Representative to the FLC
“Discovery to Commercialization: New Immunotherapy for Rare Childhood Cancer, Neuroblastoma”
Prior to a groundbreaking discovery by scientists supported by the NCI, fewer than 40 percent of children with high-risk neuroblastoma lived five years after diagnosis. Now an immunotherapy 30 years in the making, ch14.18, UnituxinTM (dinutuximab), is providing new hope for infants and children with this rare cancer. On March 10, 2015, the U.S. Food and Drug Administration approved Unituxin™ (dinutuximab also known as ch14.18) as part of first-line therapy for pediatric patients with high-risk neuroblastoma, a rare cancer that most often occurs in young children. On August 17, 2015, the European Commission (EC) also granted Marketing Authorization for Unituxin. “Discovery to Commercialization: New Immunotherapy for Rare Childhood Cancer, Neuroblastoma” was recognized by the FLC for exemplifying T2 excellence. It was a remarkably productive, collaborative effort between the National Cancer Institute (NCI), the Frederick National Laboratory for Cancer Research (FNLCR), the Children's Oncology Group, and United Therapeutics Corporation (UTC) resulting in commercialization and approval.
To learn more see: https://techtransfer.cancer.gov/aboutttc/successstories/dinutuximabunituxin and FDA Approves First Therapy for High-Risk Neuroblastoma
Sherry Ansher, Ph.D., Regulatory Affairs Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, NCI
Donna Bialozor, NCI Technology Transfer Center
Jan Casadei, Ph.D., Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, NCI
Beverly Keseling, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research (FNLCR)
Karen Muszynski, Ph.D., Biological Resources Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, NCI
Samir Shaban, M.S., Leidos Biomedical Research, Inc. Frederick National Laboratory for Cancer Research
Malcolm Smith, M.D., Ph.D., Clinical Investigations Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, NCI
L. Mary Smith, Ph.D., United Therapeutics Corp.
Alice Yu, M.D., Ph.D., University of California in San Diego Medical Center
Pictured from left to right: Malcom Smith (winner); L. Mary Smith (winner); Paul Zielinski, FLC Executive Board Chair; Donna Bialozor (winner), Alice Yu (winner); Tom Stackhouse (NCI Associate Director); Beverly Keseling (winner); Karen Muszynski (winner); Mark Reeves, FLC Vice Chair; Ana Amar, NIH Agency Representative to the FLC; Samir Shaban (winner)