2024 Technology Showcase

Voice of the Patient
 

• “Topoisomerase III (TOP3) Inhibitors and Antiviral Compounds based on Cyanine Dyes” - E-027-2022
  Yves Pommier, M.D., Ph.D.,
  Chief, Developmental Therapeutics Branch (DTB), Center for Cancer Research (CCR), NCI
  To be presented by: Shar-Yin Huang,Ph.D., Staff Scientist, DTB, CCR, NCI
   
• “Directed Acetylation of Cytidine in Cellular mRNA through Engineered snoRNA Adapters for the Treatment of Haploinsufficiencies” - E-017-2023
  Shalini Oberdoerffer, Ph.D., Senior Investigator,
  Laboratory of Receptor of Biology and Gene Expression, CCR, NCI

Lightning Pitch
Presented by participants in the 2024 NCI Technology Transfer Ambassadors Program (TTAP)

Moderator: Suna Gulay-French, Ph.D., Technology Transfer Manager, TTC

Lunch, Poster Session / Competition, Networking, One-on-One Partnering

Technology Posters

1. "Small Molecule Ephrin (Eph) Tyrosine Kinase Inhibitors for the Treatment of Colorectal Cancer and Other Eph Growth-dependent Solid Tumors," (E-182-2019); Poster Presenter, Daphna Fertil, TTAP Ambassador
   Technology Inventors: Giovanna Tosato, M.D., Senior Investigator, Laboratory of Cellular Oncology, NCI Center for Cancer Research (CCR); Michael Diprima, Ph.D., NCI CCR; Harald Schwalbe, Ph.D., JW Goethe University, Frankfurt; Alix Troster, Ph.D., JW Goethe University, Frankfurt; Nathalie Jores, M.S., JW Goethe University, Frankfurt; Denis Kudlinzki, Ph.D., German Cancer Research Center, DKFZ
2. "Pigment Epithelium-Derived Factor Peptides and Use for Treating Retinal Degeneration," (E-028-2023)
   Poster presenter, Isadora Rocha De Abreu, TTAP Ambassador
   Technology Inventors: Patricia Becerra, Ph.D. (NEI); Alexandra Bernardo-Colon, M.S. (NEI)
3. "Methods and Kits for Measuring and Quantifying DNA Double-Stranded Breaks Using Gamma-H2AX and H2AX" (E-276-2014)
   Poster presenter, Shiran Su, Ph.D. NCI TTC Technology Transfer CRTA Fellow
   Technology Inventors: Christophe Redon, Ph.D., Research Assistant, Developmental Therapeutics Branch, NCI CCR; Yiping Zhang, Ph.D., NCI, CCR; William Bonner, Ph.D. NCI CCR; Jiuping Ji, Ph.D., NCI CCR
4. "CD28 Hinge and Transmembrane Containing Chimeric Antigen Receptors Targeting GPC2 and Use Thereof" (E-025-2022)
   Poster presenter, Kiyoharu Joshua Miyagishima, Ph.D., TTAP Ambassador
   Technology Inventors: Mitchell Ho, Ph.D., Deputy Chief, Laboratory of Molecular Biology, NCI CCR; Carol Thiele Galetto, Ph.D., NCI CCR; Nan Li, Ph.D., NCI CCR; Rosa Nguyen, M.D., Ph.D., NCI CCR; Rosandra Kaplan, M.D., NCI CCR
5. "Design and Biological Activity of Novel Stealth Polymeric Lipid Nanoparticles for Enhanced Delivery of Hydrophobic Photodynamic Therapy Drugs" (E-154-2018)
   Poster presenter, Julie Hixon, M.S., TTAP Ambassador
   Technology Inventors: Anu Puri, Ph.D., Program Director, NCI Center for Cancer Training;  Mathias Viard, Ph.D., Senior Scientist, Laboratory of Integrative Cancer Immunology (NCI CCR)
6. "Single Source-Detector Separation Approach to Calculate Tissue Oxygen Saturation" (E-037-2023)
   Poster presenter, Thien Nguyen, Ph.D., TTAP Ambassador
   Technology Inventors: Thien Nguyen, Ph.D. (NICHD); Soongho Park, Ph.D. (NICHD); Brian Hill (NICHD); Amir Gandjbakhche, Ph.D. (NICHD)
7. "Engineering RNA Devices in Human T-cells to Control Gene Expression Externally" (E-234-2023)
   Poster presenter, Barbara Murphy, M.S., TTAP Ambassador
   Lead Inventor: Yun-Xing Wang, Ph.D., Senior Investigator, Center for Structural Biology, NCI CCR
8. "Bile Acids and Other Agents that Modulate the Gut Microbiome for the Treatment of Liver Cancer" (E-229-2017)
   Poster presenter, Yonghe Ma, Ph.D., TTAP Ambassador
   Technology Inventors: Tim Greten, M.D., Deputy Chief, Thoracic and GI Malignancies Branch, NCI CCR; Chi Ma, Ph.D. NCI CCR 
9. "3-o-sulfo-galactosylceramide Analogs as Activators of Type II Natural Killer T Cells to Reduce Cancer Metastasis to the Lung" (E-100-2018)
   Poster presenter, Paul Suhwan Lee, TTAP Ambassador
   Technology Inventors: Lise Pasquet, Ph.D., NCI CCR; Jay Berzofsky, M.D., Ph.D., Chief, Vaccine Branch, NCI CCR; Amy Howell, Ph.D. University of Connecticut; Masaki Terabe, Ph.D. NCI CCR; Kaddy Camara, Ph.D. University of Connecticut
10. "T Cell Receptor Targeting CD22 for the Treatment of Lymphomas and Leukemias" (E-029-2021)
    Poster presenter, Saad Khan, M.D., Johns Hopkins University 
    Technology Inventors: Kazusa Ishii, M.D., M.P.H., Physician-Scientist Early Investigator, Center for Immuno-Oncology, NCI CCR; Christian Hinrichs, M.D., Rutgers Cancer Institute of New Jersey, formerly NCI CCR

Technology Presentations

• "PIM-Targeted PROTACs" - E-094-2022
  John Brognard, Ph.D., Senior Investigator, Laboratory of Cell and Developmental Signaling, CCR, NCI

NCI and FNL Programmatic Presentations

• CLIA Molecular Diagnostics Laboratory, Cancer Research Technology Program, FNL
  Kristen M. Pike, MS, PMP, Associate Scientist II

How to Work with the NCI and FNL

Moderator: Steven Ferguson, MBA, Deputy Director Licensing and Entrepreneurship, NIH Office of Technology Transfer

• Amanda Corbel, Partnership Alliance Manager, Partnership Development Office, FNL
• Rose Freel, Ph.D., Supervisory Technology Transfer Manager, NCI TTC
• Andrew Sinkoe, Ph.D., Founder and CEO, Sesh, Inc.
• Xiaonao Liu, Ph.D. CEO, NanoBioFAB

Dilutive and Non-Dilutive Sources of Support

Moderator: Michael Salgaller, Ph.D., Technology Analysis and Marketing Unit Supervisor, NCI TTC

• Deborah Moorad, Ph.D., CEO, CorriXR Therapeutics
• Ruchika Nijhara, Ph.D., Executive Director, Maryland Stem Cell Research Fund
• David Speer, Executive Director, Maryland Israel Development Center 
• Javeed Froozan, Ph.D., Vice President, Business Development and Strategic Alliances, Leukemia and Lymphoma Society