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2018 Technology Showcase

2018 Technology Showcase Logo

June 13 – June 16, 2018

Frederick National Laboratory Advanced Technology Research Facility Frederick, MD

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Overview

  • NCI Director Dr. Norman "Ned" Sharpless keynote address on “Innovation and Commercialization: How NCI Collaborations with Industry Benefit Patients"
  • 19 featured NCI and Frederick National Laboratory (FNL) technologies available for licensing and partnering
  • Panel discussion comprised of successful biotechnology innovators from MedImmune, MiRecule, Inc. and Veralox Therapeutics, LLC sharing their insights about NIH as a technology development partner
  • Opportunities to learn about how license from and collaborate with NCI and FNL
  • An interactive poster session highlighting 12 NCI technologies available for licensing and partnering presented by the NCI Technology Transfer Ambassadors Program, and an additional poster highlighting the Center for Advanced Preclinical Research (CAPR)
  • Opportunities to learn how to access resources available at the FNL
Frederick National Laboratory

Detailed Event Schedule

Event Agenda
Program Schedule Topics and Events
7:30 – 8:30 a.m.

Check-in / Registration
8:30 – 8:45 a.m.

Welcome and Introduction

Ethan Dmitrovsky, M.D., President of Leidos Biomedical Research, Laboratory Director of the FNL

Jan H. Gardner, County Executive, Frederick County, Maryland
8:45 – 9:15 a.m.

Thomas Stackhouse, Ph.D., Associate Director, NCI TTC

Keynote:

Norman E. "Ned" Sharpless, M.D., NCI Director – “Innovation and Commercialization: How NCI Collaborations with Industry Benefit Patients”​
9:15 – 9:30 a.m.

NCI Technology Transfer Center Overview

Michael Salgaller, Ph.D., Invention Development and Marketing Supervisor, NCI TTC
9:30 – 10:45 a.m.

Technology Session 1

Moderator: Michael Salgaller, Ph.D., NCI TTC

  • "Improved Englerin A Analogues for Kidney Cancer Therapeutics” – E-140-2017
    Presenter: John Beutler, Ph.D., Molecular Targets Program, NCI, CCR
  • “Optical Trap Methods to Determine the Viscoelastic Properties of Biological Materials” – E-251-2015
    Presenter: Kandice Tanner, Ph.D., Laboratory of Cell Biology, NCI, CCR
  • "Potent Inhibitors of Non-Druggable Oncoproteins”
    Associated technologies: “Synthetic Lipopeptide Inhibitors of RAS Oncoproteins” E-293-2010, “Peptide Inhibitors for Viral Infections and as Anti-inflammatory Agents” E-167-2010 and "Anti-bacterial Treatments Using Peptide-Based Inhibitors of the STAT3-IL10 Pathway" E-278-2014
    Presenter: Nadya Tarasova, Ph.D., Cancer and Inflammation Program, NCI, CCR
  • “Nanoscale 3-D imaging of cells and tissue by FIB-SEM”
    Presenter: Kedar Narayan, Ph.D., Center for Molecular Microscopy, FNL
  • “Small Molecule Inhibitors of Drug Resistant Forms of HIV-1 Integrase” – E-093-2013
    Presenter: Stephen Hughes. Ph.D., Retroviral Replication Laboratory, NCI, CCR
10:45 - 11:00 a.m.

Break and Poster Session
11:00 a.m. – 12:00 p.m.

Technology Session 2

Moderator: Richard Griffin, AICP, CEcD, Director, The City of Frederick, Department of Economic Development

  • “Gene Editing in Cancer Research”
    Presenter: Raj Chari, Ph.D., Genome Modification Core, FNL
  • “RNA Nanoparticle Technologies for Use in Developing Cancer Therapeutics”
    (“Nucleic Acid Nanoparticles for Triggering RNA Interference” ) – E-156-2014
    Presenter: Bruce Shapiro, Ph.D., RNA Biology Laboratory, NCI, CCR
  • “Renal Carcinoma Biomarkers” E-317-2008
    Presenter: Josip Blonder, M.D., Antibody Characterization Laboratory, Cancer Research Technology Program, FNL
  • "New Technologies for the Analysis of Exosomes in Precision Medicine"
    Presenter: Clare Jones, M.D., Ph.D., Vaccine Branch, NCI, CCR
12:20 – 12:20 p.m.

Poster Pitches

Representatives from the NCI Technology Transfer Ambassadors Program (TTAP) will present the following posters highlighting technologies available for licensing and/or partnering:

  1. “Human Monoclonal Antibodies Targeting Glypican-2 in Neuroblastoma” – E-090-2013
    Inventor: Mitchell Ho, Ph.D., Laboratory of Molecular Biology, NCI, CCR
    Presented by: NCI TTAP Ambassador, Jyoti Roy, Ph.D.
  2. “Video Monitoring and Analysis System for Vivarium Cage Racks” – E-090-2013
    Inventor: James P. Mitchell, Ph.D., Radiation Biology Branch, NCI, CCR
    Presented by: NCI TTAP Ambassador, Kazi Rahman, Ph.D.
  3. “Immunotherapeutics for Pediatric Solid Tumors” – E-007-2014
    Inventors: Rimas Orentas, Ph.D., formerly with Pediatric Oncology Branch, and Chris Chien, Ph.D.
    Presented by: NCI TTAP Ambassador, Nellie Moshkovich, Ph.D.
  4. “HMGN Polypeptides as Immune Enhancers and HMGN Antagonists as Immune Suppressants” – E-185-2008
    Inventor: De Yang, M.D., Ph.D., Cancer and Inflammation Program, NCI, CCR
    Presented by: NCI TTAP Ambassador, Jennifer Cowan, Ph.D.
  5. “Chimeric Antigen Receptors for the Treatment of Leukemia and Other Cancers” – E-133-2016
    Inventors: Terry Fry, M.D., Pediatric Oncology Branch, and Chris Chien, Ph.D.
    Presented by: NCI TTAP Ambassador, Jon Nye, Ph.D.
  6. “Diagnostic Assays for the Detection of Thyroid Cancer” – E-016-2013
    Inventor: Jeffrey Baron, M.D., Eunice Kennedy Shriver National Institute of Childhood Health and Human Development (NICHD)
    Presented by: NCI TTAP Ambassador, Delphine Lissa, Ph.D.
  7. “Multivalent Immunogenic Peptides (Vaccines) for the Treatment of Prostate and Breast Cancer” – E-047-2014
    Inventor: Lauren Wood, M.D., Vaccine Branch, NCI, CCR
    Presented by: NCI TTAP Ambassador, Sarwat Naz, Ph.D.
  8. “Implantable Medical Devices with Electric Current Retrieval Assist" – E-088-2014
    Inventor: Bradford Wood, M.D., NIH Center for Interventional Oncology, NCI, CCR
    Presented by: NCI TTAP Ambassador, Tao Liu, Ph.D.
  9. “Cancer Immunotherapy Using Virus-like Particles” – E-050-2014
    Inventor: Stanislaw Kaczmarczyk, Ph.D., and Deb Chatterjee, Ph.D., Protein Expression Laboratory, NCI, CCR
    Presented by: NCI TTAP Ambassador, Kyster Nanan, Ph.D.
  10. “Photoactivatable Lipid-based Nanoparticles as a Vehicle for Dual Agent Delivery” – E-482-2013
    Inventor: Anu Puri, Ph.D., RNA Biology Laboratory, NCI, CCR
    Presented by: NCI TTAP Ambassador, Rebecca Erwin-Cohen, Ph.D.
  11. “MYC-G-Quadruplex Stabilizing Small Molecules and Their Use” – E-053-2015
    Inventors: John Schneekloth, Ph.D., Chemical Biology Laboratory, and Beverly Mock, Ph.D., Laboratory of Cancer Biology and Genetics, NCI, CCR
    Prepared by: NCI TTAP Ambassador, Ananda Chowdhury, Ph.D.
    Presented by: Taryn Dick, Ph.D., NCI TTC, and David Calabrese, Ph.D., Chemical Biology Laboratory
  12. “Near-IR Light-cleavable Conjugates and Conjugate Precursors” – E-245-2016
    Inventor: Martin Schnermann, Ph.D., Chemical Biology Laboratory, NCI, CCR
    Prepared by: NCI TTAP Ambassador, David Wei, Ph.D.
  13. “Preclinical Evaluation of Therapeutic Compounds in Mouse Models for Cancer at the Center for Advanced Preclinical Research (CAPR)”
    Project Manager and Presenter: Ken Miller, M.S., Project Manager, Center for Advanced Preclinical Research (CAPR), NCI, CCR and Leidos Biomedical Research Inc., LASP
12:20 - 1:30 p.m.

Lunch / Networking / Poster Session
1:30 – 2:15 p.m.

Success Story Roundtable

Moderator: Tom Stackhouse, Ph.D., NCI TTC
Panelists:

  • Jon Kiburz, J.D., M.B.A., Director, Partnering & Strategy – MedImmune
  • Anthony D. Saleh, Ph.D., CEO – miRecule, Inc.
  • Jeff Strovel, Ph.D., President and CEO – Veralox Therapeutics, LLC
2:15 – 3:30 p.m.

Technology Session 3

Moderator: Ron Kaese, Director, Federal Programs. Maryland Technology Development Corporation (TEDCO)

  • “Thalidomide Analogs that Inhibit Inflammation and Angiogenesis” – E-208-2015
    Presenter: William Douglas Figg, Ph.D., NCI, CCR, Genitourinary Malignancies Branch
  • “Methods for Selection of Cancer Patients and Predicting Efficacy of Combination Therapy” – E-013-2012
    Presenter: Beverly Mock, Ph.D., Laboratory of Cancer Biology and Genetics, NCI, CCR
  • “Micro-Dose Calibrator for Pre-clinical Radiotracer Assays” – E-241-2016
    Presenter: Stephen Adler, Ph.D., NCI Molecular Imaging Program, FNL
  • “Therapeutic Developments Based on Interferon Lambda 4 (IFNL4) – E-217-2011
    Presenter: Ludmila Prokunina-Olsson, Ph.D., Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics
  • “New Weapons to Penetrate the Armor: Tools Developed at the NCI RAS Initiative to Enable Discovery of RAS Therapeutics”
    Presenter: Matt Holderfield, Ph.D., RAS Drug Discovery Group, FNL
3:30 – 3:45 p.m.

Break and Poster Session
3:45 – 4:45 p.m.

Technology Session 4

Moderator: Heather Gramm, Frederick County Department of Economic Development

  • “Small Molecule Anti-cancer Agents that Stabilize the MYC-G-Quadruplex” – E-053-2015
    Presenter: David Calabrese, Ph.D., Chemical Biology Laboratory, NCI, CCR
  • “A Vaccine Against Polymavirus-Induced Kidney Disease” – E-168-2011
    Presenter: Chris Buck, Ph.D., Laboratory of Cellular Oncology, NCI, CCR
  • “A Novel Platform for Growth Factor Antagonist Development” – E-230-2011
    Presenter: Don Bottaro, Ph.D., Urologic Oncology Branch, NCI, CCR
  • “Solutions for Integration, Access and Visualization of Large Scale Scientific Data” (FNL technology / capability)
    Presenter: Uma Mudunuri, Ph.D., Advanced Biomedical Computing Center, FNL
  • “High-Affinity Rabbit Monoclonal Antibodies for Cancer Treatment” – E-198-2012
    Presenter: Mitchell Ho, Ph.D., Laboratory of Molecular Biology, NCI, CCR
4:45 – 5:00 p.m.

Closing remarks

Jim Pannucci, Ph.D., Director Partnership Development Office, FNL
5:00 - 7:00 p.m.

Networking event (adjacent to ATRF)
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