You are here

Share:

Novel Anti-HIV Proteins from Coral Reefs

Summary
Scientists at the National Cancer Institute's Molecular Targets Laboratory have discovered that Cnidarins as a novel class of highly potent proteins capable of blocking the HIV virus from penetrating T-cells. The National Cancer Institute seeks parties interested in collaborative research to license or co-develop large-scale recombinant production of cnidarins.
NIH Reference Number
E-295-2012
Product Type
Keywords
  • cnidarin
  • anti-viral
  • HIV
Collaboration Opportunity
This invention is available for licensing and co-development.
Contact
Description of Technology

Scientists at the National Cancer Institute's Molecular Targets Laboratory have discovered that Cnidarins as a novel class of highly potent proteins capable of blocking the HIV virus from penetrating T-cells. Cnidarins were found in a soft coral collected in waters off Australia's northern coast. Cnidarins can block virus fusion/entry but do not block viral attachment. In addition, Cnidarins do not have lectin-like activity and therefore possibly a unique mechanism of action. Thus, Cnidarins may represent important new leads for HIV microbicides or for systemic therapeutics for HIV.

Potential Commercial Applications

Microbicide, Therapeutic, Research tool

Competitive Advantages
  • High potency against HIV
  • Novel Chemical composition
  • Family of related proteins
  • Unique mechanism of action
Inventor(s)

Barry OKeefe (NCI), James McMahon (NCI), Koreen Ramessar (NCI), Chang-yun Xiong (NCI)

Development Stage
Patent Status
  • U.S. Patent Filed: U.S. Patent Application Number PCT US1510797
Therapeutic Area
Updated
Monday, March 26, 2018