Technology ID
TAB-4065
Novel Anti-HIV Proteins from Coral Reefs
E-Numbers
E-295-2012-0
Lead Inventors
O'Keefe, Barry
Co-Inventors
McMahon, James
Ramessar, Koreen
Xiong, Chang-yun
Applications
Therapeutics
Therapeutic Areas
Infectious Disease
Development Stages
Pre-clinical (in vivo)
Lead IC
NCI
ICs
NCI
Scientists at the National Cancer Institute's Molecular Targets Laboratory have discovered that Cnidarins as a novel class of highly potent proteins capable of blocking the HIV virus from penetrating T-cells. Cnidarins were found in a soft coral collected in waters off Australia's northern coast. Cnidarins can block virus fusion/entry but do not block viral attachment. In addition, Cnidarins do not have lectin-like activity and therefore possibly a unique mechanism of action. Thus, Cnidarins may represent important new leads for HIV microbicides or for systemic therapeutics for HIV.
Competitive Advantages:
- High potency against HIV
- Novel Chemical composition
- Family of related proteins
- Unique mechanism of action
Commercial Applications:
Microbicide, Therapeutic, Research tool
Licensing Contacts
Patents
- US
Provisional (PRV) 61/925,347
Filed on 2014-01-09
Status: Abandoned - Patent Cooperation Treaty
(PCT) PCT/US2015/010797
Filed on 2015-01-09
Status: Expired - Australia
National Stage 2015204680
Filed on 2015-01-09
Status: Issued - Canada
National Stage 2935123
Filed on 2015-01-09
Status: Pending - European Patent
National Stage 15701450.7
Filed on 2015-01-09
Status: Issued - US Patent 11,034,736
Filed on 2016-07-07
Status: Issued - Germany
European patent (EP) 15701450.7
Filed on 2016-06-29
Status: Issued - France
European patent (EP) 15701450.7
Filed on 2016-06-29
Status: Issued - United Kingdom
European patent (EP) 15701450.7
Filed on 2016-06-29
Status: Issued
Collaborations
- Licensing
- Collaboration
Date Published