In collaboration with surgery specialists from Johns Hopkins University, researchers at the National Cancer Institute (NCI) developed novel hydrogel compositions and methods of using them in the microsurgical suturing of blood vessels, which is particularly beneficial for surgeons in whole tissue transplant procedures. The lead candidate electropositive hydrogels, called APC1, was demonstrated in anastomosis mice models to be well tolerated, biocompatible, and non-toxic. Synthetic preparation of APC1 is simple, and has been easy to use by surgeons to accomplish anastomosis in animal models.
Studies demonstrate that performing anastomosis with the aid of APC improves vessel patency and drastically decreases the time of the suturing. Additionally, in comparison studies, APC1 hydrogel treatment is associated with less inflammation and scar tissue formation. There are potential additional applications for the APC1 hydrogel in military operations, commercial veterinary applications, and scientific operations of laboratory animal models.
This technology is co-owned by and was co-developed with surgical specialists from Johns Hopkins University. Experiments are underway to test biocompatibility and toxicity in rhesus macaques and pigs.
- Vascular surgical aid
- Utilized by the military in combat surgeries
- Clinical research to suture laboratory animals
- Commercial veterinary applications
- Greater stability in the presence of thiol nucleophiles
- More facile and higher yielding synthetic preparation
- Successfully utilized for in vivo surgical applications
Joel Schneider, Daniel Smith, Katelyn Nagy, Gerald Brandacher, Gabriel Brat, Yong Huang, Dedi Tong, Johanna Grahammer
Smith DJ, et al. A multiphase transitioning peptide hydrogel for suturing ultra-small vessels [PMID 26524396]
- U.S. Patent Filed: U.S. Patent Application Number , Filed 22 Jan 2016