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A Dendritic Cell Vaccine to Immunize Cancer Patients Against Mutated Neoantigens Expressed by the Autologous Cancer

Summary
Researchers at the National Cancer Institute (NCI) have developed a dendritic cell vaccine for treating multiple cancer types. The NCI seeks licensing and/or co-development research collaborations to bring this invention to the public.
NIH Reference Number
E-280-2016
Product Type
Keywords
  • Dendritic Cells, Immunotherapy, Vaccines, Cancer, T Cells, Neoantigens, Rosenberg
Collaboration Opportunity
This invention is available for licensing and co-development.
Contact
Description of Technology

Vaccines against non-viral cancers target mainly differentiation antigens, cancer testis antigens, and overexpressed antigens.  One common feature to these antigens is their presence in central immunological tolerance. Using these vaccines, T cells underwent depletion of high avidity clones directed against such antigens. This depletion can cause the loss of T cells bearing high affinity T cell receptors (TCRs) for their cognate antigens which have superior cytotoxic capacity, longer persistence in the tumor microenvironment, and decreased susceptibility to immune suppression.

The Surgery Branch of the National Cancer Institute (NCI) has identified more than 200 immunogenic epitopes from multiple cancer types including melanoma, ovarian, colorectal, lung and breast cancers. To use those defined neoantigens for therapeutic purposes, NCI researchers have developed a personalized dendritic cell (DC) vaccine.  Monocytes are isolated from patients’ apheresis, differentiated into DCs, loaded with immunogenic peptides and matured using a combination of cytokines and Toll-Like Receptor (TLR) ligands. These cells can then be administered to patients to prompt tumor-specific high avidity T cells against cancer-specific antigens.  This pipeline can be applied to any cancer type and can be completed rapidly.

The NCI, Surgery Branch, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize this dendritic cell vaccine. 

Potential Commercial Applications
  • Treatment of multiple cancer types
  • Personalized to the patient 
Competitive Advantages
  • Increased cytotoxic capacity
  • Increased persistence in the tumor microenvironment
  • Decreased susceptibility to immune suppression
Inventor(s)
Development Stage
Publications

Gros et al., Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients.  [PMID 26901407]

Tran et al., Immunogenicity of somatic mutations in human gastrointestinal cancers. [PMID 26516200]

Patent Status
  • U.S. Provisional: U.S. Provisional Patent Application Number 62/398,963 , Filed 23 Sep 2016
  • U.S. Patent Filed: U.S. Patent Application Number PCT/US2017/051981 , Filed 19 Sep 2017
Therapeutic Area
Updated
Wednesday, August 15, 2018