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Silica-Coated Nanodiamonds for Imaging and Delivery of Therapeutic Agents

Summary
The NCI Radiation Oncology Branch and the NHLBI Laboratory of Single Molecule Biophysics seek parties to co-develop fluorescent nanodiamonds for use as in vivo and in vitro optical tracking probes toward commercialization.
NIH Reference Number
E-175-2012
Product Type
Keywords
  • Diagnostic
  • imaging
  • nanodiamond
  • silica-coated
  • functionalized
Collaboration Opportunity
This invention is available for licensing.
Contact
Description of Technology

The NCI Radiation Oncology Branch and the  NHLBI Laboratory of Single Molecule Biophysics seek parties to co-develop fluorescent  nanodiamonds for use as in vivo and in vitro optical tracking probes toward commercialization.  

NCI and NHLBI investigators invented a robust and easily implemented method of synthesizing silica-coated nanodiamonds for imaging and therapeutic applications. A patent estate covering these methods is offered for licensing to commercial entities. The method generally includes coating nanodiamonds with a silica precursor, e.g, tetraethylorthosilicate (TEOS), inside liposomes. The liposomes are then removed to yield a final product that is stable, monodisperse, and easy to functionalize. 

Potential Commercial Applications
  • Imaging
  • Drug delivery
Competitive Advantages
  • Small size
  • Physiologically inert carrier
  • Monodisperse
  • Stable in aqueous solution
  • Readily functionalized
  • Biological activity is determined more efficiently than chemical analysis
  • High Specificity and selectivity
Development Stage
Publications

Yu SJ, et al. Bright fluorescent nanodiamonds: no photobleaching and low cytotoxicity.  [PMID 16351080]

Wilson RM. Nanodiamonds are promising quantum probes of living cells. [DOI 10.1063/PT.3.1204]

Chow EK, et al. Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment.  [PMID 21389265]

Krueger A. New carbon materials: biological applications of functionalized nanodiamond materials. [PMID 18033700]

Patent Status
  • U.S. Patent Filed: U.S. Patent Application Number 61/672,996, Filed 18 Jul 2012
  • U.S. Provisional: U.S. Provisional Patent Application Number 61/711,702, Filed 09 Oct 2012
Therapeutic Area
Updated
Tuesday, April 17, 2018