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Use of Heterodimeric IL-15 in Adoptive Cell Transfer

Summary
Researchers at the National Cancer Institute (NCI) have developed a technology that provides methods of performing adoptive cell transfer (ACT), an immunotherapeutic approach for cancer treatment, by administering a heterodimeric Interleukin 15/Interleukin 15 receptor alpha (IL-15/IL-15Rα) complex (hetlL-15) in the absence of lymphodepletion, thereby eliminating any lymphodepletion-associated detrimental side effects.
NIH Reference Number
E-132-2016
Product Type
Keywords
  • Adoptive Cell Transfer
  • ACT
  • Lymphodepletion
  • Immunotherapy
  • Interleukin 15
  • IL-15
  • Receptor Alpha Complex
  • HetIL-15
Collaboration Opportunity
This invention is available for licensing and co-development.
Contact
Description of Technology

Adoptive cell transfer (ACT) is a promising immunotherapeutic approach for cancer treatment. During ACT, if a patient is subjected to lymphodepletion prior to cell transfer, there is an observed improvement in a patient’s response to treatment. However, lymphodepletion is associated with detrimental effects, including severe immune dysfunction that persists after treatment.

Researchers at the National Cancer Institute (NCI) have developed a technology that provides formulations and dosage protocols for administration of hetIL-15 to replace lymphodepletion in ACT. Administration of hetIL-15 may not only replace lymphodepletion in ACT, it may also increase ACT efficiency due to its ability to increase lymphocyte growth, differentiation, and tumor entry. NCI’s technology provides specific dosage and treatment schedules of hetIL-15 to improve tumor entry and increase and maintain the number of tumor-specific lymphocytes in the tumor with an acceptable toxicity profile. Therefore, administration of hetIL-15 with ACT can replace lymphodepletion in cancer immunotherapy protocols. Thus, the NCI’s cancer immunotherapeutic protocol replicates the advantages of lymphodepletion preconditioning of the host for successful ACT while avoiding the adverse effects associated with lymphodepletion.

Potential Commercial Applications
  • CAR T-cell therapy
  • Adoptive transfer of lymphocytes
Competitive Advantages
  • Allows Adoptive Cell Transfer (ACT) or CAR T-cell therapy without lymphodepleting treatment
  • May support engraftment, function and maintenance of ACT cells administered with or without prior lymphodepletion
Development Stage
Publications

Ng SSM, et al. Heterodimeric IL-15 treatment enhances tumor infiltration, persistence and effector functions of adoptively transferred tumor-specific T cells in the absence of lymphdepletion. [PMID 27986749]

Patent Status
  • U.S. Patent Filed: U.S. Patent Application Number PCT/US2017/26447, Filed 06 Apr 2017
Related Technologies
  • E-257-2009
  • E-254-2005
Therapeutic Area
Updated
Thursday, September 7, 2017