Cancer cells may acquire drug resistance after prolonged chemotherapy. In many cases, cancer cells develop resistance to several drugs with distinct structures and modes of action. This multi-drug resistance phenomenon increases the complexity of cancer treatment.
Researchers at the National Cancer Institute (NCI) have derived an Adriamycin-resistant cell line, NCI/ADR-RES, from human ovarian cancer cells. The parental cell line is OVCAR-8, obtained from a high-grade ovarian serous adenocarcinoma. NCI/ADR-RES is resistant to Adriamycin and found to express high levels of the Multi-Drug Resistance 1 (MDR1) protein – also known as P-glycoprotein. The cell line was extensively characterized and proven useful in identifying compounds subject to multi-drug resistance. NCI/ADR-RES was deposited into the Division of Cancer Treatment and Diagnosis (DCTD) Developmental Therapeutics Program (DTP) Tumor Repository and added to the NCI-60 Human Tumor Cell Lines Screen, along with parental OVCAR-8. Molecular characterization data are publicly available on the DTP website.
NCI is seeking parties to non-exclusively license the ADR-RES cell line.
- Research tool to study the multi-drug resistance phenomenon in cancer
- Research tool to study Adriamycin resistance in ovarian cancer
- Research tool to study the overexpression of MDR1 (P-glycoprotein) in cancer
- Extensively characterized and documented human ovarian adenocarcinoma cell line
- Part of the NCI anti-cancer drug screen human cell line panel (NCI-60 Human Tumor Cell Lines Screen)
- Molecular characterization data are publicly available
Kenneth H Cowan MD PhD (NCI)
Vert A, et al. Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance. [PMID 29379303]
Scudiero DA, et al. Cell line designation change: multidrug-resistant cell line in the NCI anti-cancer screen. [PMID 9625176]
Batist G, et al. Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. [PMID 3782078]
- Research Material: NIH will not pursue patent prosecution for this technology