- Diagnostics
- Research Tools
- Jaime Greene
Researchers at the NCI Radiation Oncology Branch and NIH CIT Center for Molecular Modeling developed a tetrahydroxamate chelation technology that provides a more-stable Zr-89 complex as an immuno-PET cancer imaging agent. In either the linear or the macrocyclic form, the tetrahydroxamate complexes exhibit greater stability as chelating agents compared to Zr-89 complexed to the siderophore desferrioxamine B (DFB), a trihydroxamate, which represents the current state of the art chemistry and the agent currently in clinical use.
In the Zr-89-DFB imaging agents, Zr-89 dissociates from the chelate, resulting in an increasing radioisotope accumulation in the bone 2-3 days after injection. In vitro studies demonstrate the tetrahydroxamate-chelated Zr-89 remained kinetically inert for seven or more days, thereby reducing the amount of Zr-89 that is released compared to the complex containing DFB.
- PET imaging, especially for cancer and in particular Immuno-PET imaging
- High stability with low toxicity
Francois Guerard (NCI), Yong Sok Lee (CIT), Martin Brechbiel Brechbiel (NCI)
- Prototype
Guerard F, et al. [PMID 23250287]
Guerard F, et al. [PMID 2470517]
- U.S. Patent Filed: U.S. Patent Application Number 61/779,016, Filed 13 Mar 2013
- Foreign Filed: EP - Patent Application 14779019
- E-194-2007
- E-226-2006
- E-067-1990
- Cancer/Neoplasm