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Method for Generating Pluripotent and Multipotent Cells

Summary
This technology represents a safe yet highly efficient strategy for somatic cell reprogramming, and has broad applicability for basic research, disease modeling, and regenerative medicine.
NIH Reference Number
E-086-2012
Product Type
Keywords
  • iPS cells
  • cell-reprogramming
  • cell-based therapies
  • regenerative medicine
Collaboration Opportunity
This invention is available for licensing and co-development.
Contact
Description of Technology

Research and clinical applications of induced pluripotent stem (iPS) cells are currently limited by reprogramming methods that may modify the host genome, and therefore be potentially unsafe and problematic for use in basic research, cell-based therapies, and drug-discovery applications. 

Researchers at the National Cancer Institute’s Laboratory of Pathology have overcome this challenge by using CD47 inhibiting peptides, antibodies, and morpholinos to generate and expand iPS cells.  This technology represents a safe yet highly efficient strategy for somatic cell reprogramming, and has broad applicability for basic research, disease modeling, and regenerative medicine. The NCI seeks partners interested in licensing or collaborative research to co-develop methods for generating and expanding iPS cells and lineage-committed stem cells using a single agent.

Potential Commercial Applications
  • iPS cell generation (human and murine)
  • Lineage-committed stem cell generation
  • Regenerative medicine
  • Stem cell therapy
Competitive Advantages
  • Virus-free reprogramming
  • Genomic integration-free
  • Allows generation and maintenance of a ready supply of iPS cells and fate-committed stem cells using a single defined agent
  • Maintains cell growth and morphology for at least 6 months
Development Stage
Publications

Kaur S et al. Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors [PMID: 23591719]

Patent Status
  • U.S. Patent Filed: U.S. Patent Application Number 14/390,134, Filed 02 Oct 2014
  • Foreign Filed: Canadian - Patent Application 2869913, Filed 07 Oct 2014
Related Technologies
Therapeutic Area
Updated
Tuesday, April 17, 2018