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Polyclonal Anti-Rat Acetylserotonin Methyltransferase (ASMT)

The Eunice Kennedy Shriver National Institute of Child Health and Human Development seeks parties to non-exclusively license polyclonal anti-rat acetylserotonin methyltransferase (ASMT).
NIH Reference Number
Product Type
  • acetylserotonin, methyltransferase, immunological assay
Collaboration Opportunity
This invention is available for licensing.
Description of Technology

Rabbits were immunized with peptide corresponding to residues 308-321 of rat ASMT.  Human ASMT and ASMT of other species do  not have this sequence and the anti-ASMT would be specific for the rat ASMT.  Antibody specificity to the peptide used as immunogen was verified by blocking the antibody’s reactivity with pineal gland tissue with the immunogen.  In western blot, the rabbit anti-ASMT serum only reacts with pineal gland and retinal tissue and identifies a band corresponding to the size of the predicted protein.  In immunohistochemistry, the reagents only identify pinealocytes.

Potential Commercial Applications
  • Useful in detecting rat acetylserotonin methyltransferase in immunological assays, including western blot and immunohishtochemistry.
Competitive Advantages
  • Serum only reacts with pineal gland and retinal tissu

David C. Klein (NICHD), Steven L. Coon (NICHD)

Development Stage

Steven L. Coon [pubmed: 26950199]

M.F. Rath et al. [PMID: 26950199]

F.G. Amara et al. [PMID: 26950199]

M. Møller [PMID: 26950199]

D.C. Klein [PMID: 26950199]

Patent Status
  • Research Material: NIH will not pursue patent prosecution for this technology
Therapeutic Area
Tuesday, April 3, 2018