In silico design of RNA nanoparticles

RNA nanoparticles have the potential to serve as excellent drug or imaging delivery systems due to their designability and versatility. Furthermore, the RNA nanoparticles of the invention are also capable of self-assembly and potentially form nanotubes of various shapes which offer potentially broad uses in medical implants, gene therapy, nanocircuits, scaffolds and medical testing.

This technology, which was co-invented by researchers at National Cancer Institute and the University of California at Santa Barbara (UCSB), describes the computational design of various RNA nanoparticles. These polyvalent nanoparticles utilize RNA motifs as building blocks that give the particles their unique characteristics.  The motifs can be pre-defined and chosen to give the particles desired characteristics (e.g. size and shape) tailored for a variety of applications. The polyvalent particles can utilize multiple unique positions to carry functional groups for cell recognition (e.g. cancer cells), therapy and detection. For therapeutic or detection applications the particles typically encompass at least two functional groups, a therapeutic or imaging agent and a targeting agent that will direct the particles to the targeted tissue.

Proof of concept has been demonstrated computationally and experimentally for a variety of RNA nanoparticle structures, including synthesis of an RNA Nanoring. NCI is seeking collaborators to perform the laboratory testing necessary to translate computational RNA nanoparticle research into therapeutics, diagnostics, and other applications. Collaborations regarding any aspect of the technology will be considered.