- Taryn Dick
This technology describes additional methods of using the griffithsin anti-viral polypeptides described in related NCI invention (reference number E-106-2003). Specifically, this invention describes the use of GRFT to inhibit viral infection of hepatitis C viral infection, a severe acute respiratory syndrome (SARS) viral infection, an H5N1 viral infection, or an Ebola viral infection.
Issued patents: US 8,088,729 (Jan. 3, 2012) and foreign rights in France, Germany, Ireland, United Kingdom, Switzerland (all granted)
- Microbicide that can prevent viral transmission
- Therapeutic against enveloped virus-mediated diseases
- Highly Potent Broad-Spectrum Antiviral Lectin
- Superior in vitro and in vivo antiviral activity with minimum host toxicity against a variety of clinically relevant, enveloped viruses.
Barry R. OKeefe (NCI), James McMahon, Toshiyuki Mori (NCI)
- Discovery (Lead Identification)
Mori T. et al., Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. [PMID 15613479]
Giomarelli B, et al. Recombinant production of anti-HIV protein, griffithsin, by auto-induction in a fermentor culture [PMID: 16300962]
- U.S. Patent Issued: U.S. Patent Number 8,088,729, Issued 03 Jan 2012
- Infectious Diseases