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Novel Anti-HIV Compounds Using Peptides or Peptide Mimetics

Summary
Novel class of anti-HIV compounds that inhibit viral recognition process and nuclear export activity.
NIH Reference Number
E-019-2014
Product Type
Keywords
  • Anti-viral
  • HIV
Collaboration Opportunity
This invention is available for licensing.
Contact
Description of Technology

The subject invention describes a new class of compounds (such as peptides or mimetics) that target viral RNAs and inhibit the viral life cycle by blocking the viral recognition process. More specifically, these compounds are the first against an RNA Target - currently there are no clinical drugs against RNA targets in the treatment of any type of human disease. Anti-HIV drugs currently on the market are complicated by the development of resistance and substantial side-effects; however, these compounds would unlikely develop any side effects because of their very high specificity against only viral RNA. In addition, these compounds may be further linked to a detectable label. Thus, these compounds have the potential to be used as a new class of systemic drugs for the treatment of HIV infection and to be developed into diagnostic kits or devices.

Potential Commercial Applications
  • Anti-viral HIV therapeutic
  • HIV Diagnostic
Competitive Advantages
  • New class of compound
  • Inhibits the viral recognition process and nuclear export activity
  • High specifity only to HIV RNA
  • Ease of permeability through cell membrane because compound is positively charged.
Inventor(s)

Yun-Xing Wang (NCI), Liu Yu (NCI), Ping Yu (NCI), Ina O'Carroll (NCI)

Development Stage
Publications

Fang X, et al. [PMID 24243017]

Patent Status
  • U.S. Patent Filed: U.S. Patent Application Number 61/894,849, Filed 23 Oct 2013
Therapeutic Area
Updated
Thursday, July 19, 2018