Nitroxyl (HNO) has recently emerged as a prospective pharmacological agent. Studies of the chemistry of HNO have led to an understanding that HNO is vastly different from nitric oxide (NO). HNO displays unique cardiovascular properties and has been shown to have positive effects in failing hearts without changing heart rate, and also has been shown to have beneficial effects in ischemia reperfusion injury. In addition to the observed cardiovascular effects, HNO has shown initial promise in the realm of cancer therapy. HNO has been demonstrated to inhibit a key glycolytic enzyme. Due to the Warburg effect, inhibiting glycolysis is an attractive target for inhibiting tumor proliferation. HNO has recently been shown to inhibit tumor proliferation in mouse xenografts. Additionally, HNO inhibits tumor angiogenesis and induces cancer cell apoptosis.
The National Cancer Institute's Cancer and Inflammation Program discovered HNO releasing compounds and methods of treating various diseases with such compounds.
- Potential treatment for cardiovascular disease, ischemia, and cancer.
- Tool to probe the role of HNO in normal physiology and disease states.
- Alleviated toxicity associated with chronic NSAID use
- Controlled release of HNO
David A Wink (NCI), Larry K Keefer (NCI)
- U.S. Patent Filed: U.S. Patent Application Number 61/315,604, Filed 19 Mar 2010