Substance use disorder is a chronic medical condition, taking its toll on our public health care and judicial systems in an economically unsustainable way. More than 20 million Americans suffer from substance use disorders. Certainly, the development of prevention and treatment options as alternatives to incarceration is the appropriate and ethical solution to this escalating global problem. Although the recent opioid epidemic has redefined public perception of drug dependence, addiction is not a single illness for which one treatment modality will cure all. Efforts to develop medications to treat this family of disorders must be tailored to the specific substance or substances of abuse, co-morbidities with other neuropsychiatric illnesses, and ultimately individual treatment needs, which significantly increases the challenge.
The development of medications to treat cocaine and methamphetamine use disorders has been unsuccessful, leaving this patient population without pharmacotherapeutic options. As the dopamine transporter (DAT) plays a prominent role in the reinforcing effects of these psychostimulant drugs that can lead to addiction, atypical DAT inhibitors have been developed that prevent cocaine or methamphetamine from binding to DAT, but they themselves do not display the psychostimulant or rewarding properties that would predict their addictive liability.
- Treatment of substance use disorders
- Treatment of ADHD
- Treatment of depression
- Treatment of narcolepsy
- Treatment of cognitive impairment
- There are currently no FDA approved medications to treat cocaine and/or methamphetamine use disorders
- Compounds do not produce psychostimulant-like behavioral effects and attenuate behaviors induced by cocaine and/or methamphetamine
- Mild elevation of brain dopamine and serotonin levels
- Analogues have potentially lower effective doses
- Potentially bioavailability than modafinil
- Potentially improved water solubility over modafinil
Amy Newman, Rachel Slack, JoLynn Giancola
Giancola JB, et al. Discovery of novel DAT inhibitors based on the modafinil scaffold for the treatment of psychostimulant abuse. Poster at: the Soc. For Neurosciences meeting, Nov. 14, 2017, Washington D.C.
- U.S. Provisional: U.S. Provisional Patent Application Number 62/585,058 , Filed 13 Nov 2017