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Showing 1-18 of 18 results found

A peptide hydrogel for use in vascular anastomosis

Surgery specialists from Johns Hopkins University, in collaboration with researchers at the National Cancer Institute (NCI), developed peptide hydrogel compositions and methods to suture blood vessels during microsurgery. The hydrogels particularly benefit surgeons in whole tissue transplant procedures. The NCI seeks co-development research collaborations for further development of this technology.

Devices

Bac-2-the-Future: An Improved System for Production of Recombinant Baculovirus

The National Cancer Institute (NCI) seeks licensing of Bac-2-the-Future, an improved system for the production of recombinant baculovirus.

Research Tools

Cell Line for Production of Recombinant Human Tissue Inhibitor of Metalloproteinase-2

Recombinant human tissue inhibitors of metalloproteinases (rhTIMP-2) have been shown to suppress tumor growth and tumor-associated angiogenesis. NCI Radiation Oncology Branch (ROB) researchers have developed a unique HEK-293F cell line which stably expresses rhTIMP-2, increasing the production of TIMP-2 to quantities sufficient to be used for testing and development as a therapeutic for various cancers, ischemic diseases (myocardial infarct and cerebrovascular infarct), and neurodegenerative diseases.

Research Tools

Conformational Restriction of Cyanine Fluorophores in Far-Red and Near-IR Range

Researchers at the National Cancer Institute (NCI) seek licensing and/or co-development research collaborations for a new class of conformationally restricted cyanine dyes

Diagnostics

Engineered Biological Pacemakers

The National Institute on Aging's Cellular Biophysics Section is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize biological pacemakers.

Devices

Exo-Clean Technology for Purifying Extracellular Vesicle Preparations from Contaminants

Researchers at the National Cancer Institute (NCI) developed a novel biophysical technique to purify extracellular vesicles (EVs) from contaminants such as proteins and unbound labels. The NCI seeks licensees and/or co-development research collaborations to further advance this technology for EV-based biomarkers and therapeutics to treat a wide range of diseases.

Research Tools

Eye Tracking Application in Computer Aided Diagnosis and Image Processing in Radiology

The National Institute of Health - Clinical Center (NIH-CC) seeks licensing and/or co-development of a system and method for tracking eye movement to increase the efficacy of visual diagnoses by radiologists.

Devices
Software

Improved PE-based Targeted Toxins: A Therapeutic with Increased Effectiveness

The National Cancer Institute's Laboratory of Molecular Biology seeks interested parties to co-develop targeted toxins as therapeutic agents for cancer treatment.

Therapeutics

Learning to Read Chest X-Rays: Recurrent Neural Cascade Model for Automated Image Annotation

The National Institutes of Health - Clinical Center (NIH-CC) seeks to license and/or co-develop methods of reading chest x-rays using a deep learning models to detect a disease and describe its contents.

Software

Machine Learning and/or Neural Networks to Validate Stem Cells and Their Derivatives for Use in Cell Therapy, Drug Delivery, and Diagnostics

Researchers at the National Institute of Health (NIH) and National Institute of Standards and Technology (NIST) seek licensing or co-development partners for a method to predict functions, identity, disease state, and health of stem cells using machine learning.

Software

National Cancer Institute dosimetry system for Nuclear Medicine (NCINM) Computer Program

The National Cancer Institute (NCI) seeks licensees for a novel computer program performing radiation dose calculations for diagnostic and therapeutic nuclear medicine.

Software

National Cancer Institute dosimetry system for Radiography and Fluoroscopy (NCIRF) Computer Program

The National Cancer Institute (NCI) seeks licensees for a novel computer program that can perform radiation dose calculations for radiography and fluoroscopy procedures.

Software

New Insect Sf9-ET Cell Line for Determining Baculovirus Titers

The National Cancer Institute (NCI) seeks licensing partners for a novel modified insect cell line, Sf9-ET, that can quickly and efficiently determine baculovirus titers during the expression of recombinant proteins from a baculovirus-based protein expression system.

Research Tools

Optical Configuration Methods for Spectral Scatter Flow Cytometry

Scientists at the National Cancer Institute (NCI) seek licensees or co-development partners for a multispectral detection method capable of discriminating different Molecular NanoTag components. The capacity to discriminate further increases the sensitivity of detection for NanoTag molecules. Adaptations of this technology could also apply to incorporate spectral scatter detection in other cytometric and microfluidic systems.

Research Tools

Photoactivatable Lipid-based Nanoparticles as a Vehicle for Dual Agent Delivery

Researchers at the National Cancer Institute (NCI) RNA Biology Laboratory have developed nanoparticles that can deliver an agent (i.e., therapeutic or imaging) and release the agent upon targeted photoactivation allowing for controlled temporal and localized release of the agent.

Therapeutics

SMAD3 Reporter Mouse for Assessing TGF-ß/Activin Pathway Activation

Researchers at the National Cancer Institute (NCI) developed a novel mouse for the detection of TGF-ß signaling. This mouse provides the opportunity to study TGF-ß signaling in vivo and may be a useful model for preclinical pharmacology studies. The NCI seeks licensees for the TGF-ß reporter mouse.

Research Tools

Strategies to Protect Mammalian Neural Tissue Against Cold and Potentially Other Metabolic Stresses and Physical Damages

The National Eye Institute (NEI) seeks research co-development or licensees for making research- or clinical-grade preservation solutions for cold-sensitive organ transplantation or protection of brain injury or trauma during surgery.

Research Tools

Topical Sodium Nitrate Ointment for Sickle Cell Disease

The National Institutes of Health, through The National Institutes of Health - Clinical Center (NIH-CC) and the National Heart Lung and Blood Institute (NHLBI), seeks licensing and/or co-development partners for a nitric oxide cream for the treatment of ulcers associated with sickle cell disease.

Therapeutics

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