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A Murine Model of Inflammation Based on Chronic Expression of Interferon-Gamma

The National Cancer Institute (NCI) has a novel mouse model of autoimmunity based on chronic interferon-gamma expression (ARE-Del). This mouse can be used as an in vivo model to study female-biased autoimmune diseases, including: Systemic Lupus Erythematosus, Primary Biliary Cholangitis, and Ovarian Failure Syndrome.

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A Sensitive, High Throughput Pseudovirus-Based Papillomavirus Neutralization Assay for HPV 16 and HPV 18

This invention is a research tool for measuring protective antibody responses against Human Papilloma Viruses (HPV). The invention is available for non-exclusive license.

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Bac-2-the-Future: An Improved System for Production of Recombinant Baculovirus

The National Cancer Institute (NCI) seeks licensing of Bac-2-the-Future, an improved system for the production of recombinant baculovirus.

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Cell Lines that Constitutively Express High-Frequency KRAS and P53 Mutations and Human Leukocyte Antigens (HLAs)

The National Cancer Institute (NCI) seeks licensees for a library of cell lines stably expressing common tumor-specific antigens and human leukocyte antigens (HLAs) that can be used to identify, isolate, and expand tumor-reactive T cells.

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HIV-1 IN Mutant in a Single Round Vector

The National Cancer Institute (NCI) seeks potential non-exclusive licensees for a collection of mutated single-round vectors for testing of potential Integrase Strand Transfer Inhibitor (INSTI) and reverse transcriptase (RT) inhibitor drugs.

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Mice, Organs, and Mouse Alleles Carrying Germline and Conditional Deletions of the Zbtb7b Gene

The National Cancer Institute (NCI) seeks licensees for a mouse model of CD4+ T cell deficiency. The mice carry alleles with germline and conditional deletions of the Zbtb7b gene encoding the zinc finger transcription factor ThPOK or cKrox, essential for the development and function of CD4+ T cells.

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Molecular Nanotags for Detection of Single Molecules

Researchers at the National Cancer Institute (NCI) developed novel molecular nanotags for single biological nanoparticle detection, resolution, and sorting, by flow cytometry. The National Cancer Institute (NCI) seeks licensing and/or co-development research collaborations to further advance this technology with extremely broad biomedical, biodefense, industrial, environmental, and other applications.

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New Insect Sf9-ET Cell Line for Determining Baculovirus Titers

The National Cancer Institute (NCI) seeks licensing partners for a novel modified insect cell line, Sf9-ET, that can quickly and efficiently determine baculovirus titers during the expression of recombinant proteins from a baculovirus-based protein expression system.

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Novel Fusion Proteins for HIV Vaccine

The National Cancer Institute’s Cancer and Inflammation Program seeks parties to license gp120 and CD4-induced antibody fusion proteins for use in an HIV vaccine.

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Optical Configuration Methods for Spectral Scatter Flow Cytometry

Scientists at the National Cancer Institute (NCI) seek licensees or co-development partners for a multispectral detection method capable of discriminating different Molecular NanoTag components. The capacity to discriminate further increases the sensitivity of detection for NanoTag molecules. Adaptations of this technology could also apply to incorporate spectral scatter detection in other cytometric and microfluidic systems.

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Polymer-Cast Inserts for Cell Histology and Microscopy

The National Cancer Institute (NCI) seeks co-development partners and/or licensees for polymer-cast inserts for cell histology and microscopy; a system for high throughput three-dimensional (3D) cell culture and screening microscopy.

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