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Use of Replicators in Gene Therapy

This technology is a method of inhibiting or delaying gene silencing through specific transgene constructs that would be used for generating gene therapy vectors.

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Human Antibody for Deploying CH2-Based Therapeutics

A human antibody that could be used safely in vitro and in vivo for the detection of CH2 (Fc and IgG as well is available of out-licensing from the National Cancer Institute.

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Molecular Nanotags for Detection of Single Molecules

Researchers at the National Cancer Institute (NCI) developed novel molecular nanotags for single biological nanoparticle detection, resolution, and sorting, by flow cytometry. The National Cancer Institute (NCI) seeks licensing and/or co-development research collaborations to further advance this technology with extremely broad biomedical, biodefense, industrial, environmental, and other applications.

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Exo-Clean Technology for Purifying Extracellular Vesicle Preparations from Contaminants

Researchers at the National Cancer Institute (NCI) developed a novel biophysical technique to purify extracellular vesicles (EVs) from contaminants such as proteins and unbound labels. The NCI seeks licensees and/or co-development research collaborations to further advance this technology for EV-based biomarkers and therapeutics to treat a wide range of diseases.

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Human Synovial Sarcoma Cell Line A2243

The National Cancer Institute (NCI) seeks parties interested in licensing a human synovial sarcoma cell line (A2243). This cell line is an excellent research tool to study synovial sarcoma with a focus on chromosome translocations.

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GATA-3 Reporter Plasmids for Revealing Underlying Mechanisms in Breast Cancer

Researchers at the National Cancer Institute, Laboratory of Cancer Biology and Genetics believe that a better understanding of GATA-3 function and dysregulated during the onset and progression of breast cancer will lead to new strategies in diagnosing and treating the disease.

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Parental A2780 Ovarian Cancer Cell Line and Derivative Cisplatin-resistant and Adriamycin-resistant A2780 Cell Lines

The National Cancer Institute (NCI) seeks non-exclusive licensees for an ovarian cancer cell line, A2780, and its cisplatin- and/or adriamycin-resistant derivatives, A2780CIS and A2780ADR. These cell lines are excellent research tools to study ovarian cancer with a focus on drug resistance.

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Improved Production of Prenylated Protein in Insect Cells

The National Cancer Institute seeks parties interested licensing and/or collaborative research to co-develop research materials for improved production of prenylated proteins.

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Removal of Selected Proteins Using Light Energy: Photoimmunotherapy

The National Cancer Institute is seeking parties interested in collaborative research to co-develop or license the in vitro and in vivo removal of targets using light energy.

Therapeutics
Diagnostics
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Brain endothelial reporter cells

The National Cancer Institute seeks parties interested in co-development of safe and effective TEM5 agonists and/or antagonists that modulate WNT signaling.

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Method for Assembling Decellularized Tissue Extracellular Matrix in 3D Tumor Spheroids

National Cancer Institute (NCI) seeks licensees or co-development research collaborations for a novel method of generating microtissue spheroids that allows for creation of a self-contained spheroid integrating both cells and decellularized tissue ECM dense regions rather than cell-only spheroids.

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