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Humanized Mouse Model to Study Mesothelin (MSLN) -targeted Cancer Therapeutics: Bl6/TPO Mice

The National Cancer Institute (NCI) seeks licensees for humanized mice that express the human isomer of mesothelin (MSLN) in the thyroid. NCI created Bl6/TPO mice for studies of mesothelin as a target for research, diagnostic, or therapeutics involving human cancers.

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A Preclinical Orthotopic Model for Glioblastoma Multiforme that Represents Key Pathways Aberrant in Human Brain Cancer

The National Cancer Institute (NCI) seeks licensees for a preclinical orthotopic mouse model of glioblastoma multiforme (GBM).

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A Preclinical Model for Mutant Human EGFR-driven Lung Adenocarcinoma

The National Cancer Institute (NCI) has a human epidermal growth factor receptor- (EGFR) driven tumor mouse model of lung adenocarcinoma available for licensing.

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New Insect Sf9-ET Cell Line for Determining Baculovirus Titers

The National Cancer Institute (NCI) seeks licensing partners for a novel modified insect cell line, Sf9-ET, that can quickly and efficiently determine baculovirus titers during the expression of recombinant proteins from a baculovirus-based protein expression system.

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Bac-2-the-Future: An Improved System for Production of Recombinant Baculovirus

The National Cancer Institute (NCI) seeks licensing of Bac-2-the-Future, an improved system for the production of recombinant baculovirus.

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Tni-FNL: An Improved Trichoplusia Ni Cell Line for Protein Expression

Researchers at the National Cancer Institute (NCI) seek licensing for an improved cell line called Tni-FNL which is capable of high level expression of heterologous proteins using baculovirus expression systems.

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Device for Growing Mammalian Cells on EM Grids

A device used to hold transmission electron microscopy grids that allows adherent mammalian cells to grow on and the 3D printing software to create the device, which the NCI seeks to license.

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A Sensitive, High Throughput Pseudovirus-Based Papillomavirus Neutralization Assay for HPV 16 and HPV 18

This invention is a research tool for measuring protective antibody responses against Human Papilloma Viruses (HPV). The invention is available for non-exclusive license.

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Device to guide oxygen over cells for photo-oxidation

Device is used to guide a stream of oxygen or carbon dioxide over a dish of cells during fluorescence microscopy. Invention includes the 3D printing software to create the device. The device makes it possible to easily provide a steady source of oxygen or carbon dioxide to cells while operating a fluorescent microscope to oxidize fluorophores for later visualization in electron microscopy. NCI seeks commercial partners to license this technology.

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Optical Microscope Software for Breast Cancer Diagnosis

Researchers from NCI and Rudgers University developed methods of detecting abnormal cells in a sample using the spatial position of one or more genes within the nucleus of a cell, as well as a kit for detecting abnormal cells using such methods. The invention also provides methods of identifying gene markers for abnormal cells using the spatial position of one or more genes within the nucleus of a cell. The National Cancer Institute seeks parties interested in collaborative research to co-develop diagnostic methods for detection of cancer using spatial genome organization.

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Software

Zirconium-89 PET Imaging Agent for Cancer

This technology is a new generation of rationally designed chelating agents that improve the complexation of Zirconium-89 for PET imaging of cancers.

Diagnostics
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Immunocompetent Mouse Model for Tracking Cancer Progression

The National Cancer Institute seeks licensees or research collaborators to develop and commercialize transgenic mice having immunocompetent rat growth hormone-firefly Luciferase-enhanced green fluorescent protein.

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Lentiviral Vectors with Dual Fluorescence/Luminescence Reporters

Researchers at NCI developed twelve lentiviral vectors that express both fluorescent and luminescent markers as a single fusion protein under various gene promoters.

Diagnostics
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High-throughput Assay to Identify New Cancer Drugs

The National Cancer Institute seeks parties interested in collaborative research to evaluate or commercialize a diagnostic tool that can identify new drugs that increase chromosome instability.

Diagnostics
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Mouse Model for the Preclinical Study of Metastatic Disease

The National Cancer Institute seeks licensees for a mouse model that shows pre-clinical therapeutic response of residual metastatic disease.

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BODIPY-FL Nilotinib (Tasigna) for Use in Cancer Research

The National Cancer Institute''s Laboratory of Cell Biology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize bodipy conjugated tyrosine kinase inhibitors that are currently used in the clinic for the treatment of CML or gastric cancers.

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