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Systems and Devices for Training and Imaging an Awake Test Animal

Researchers at the National Institute on Drug Abuse (NIDA) have developed an apparatus that is used to image rodents while they are awake. The biological effects of agents on the rats can be imaged (via MRI for instance) in real time over a prolonged period of time.

Module to Freeze and Store Frozen Tissue

Researchers at the National Cancer Institute (NCI) have developed an engineered storage unit for frozen tissue, that provides a permanent base on which to mount tissue frozen in OCT and an enclosure for storage. The unit provides for chain-of-custody labeling and acts as an insulating container to protect the specimen. Other elements include devices for freezing the tissue to the base, as well as a holder for the base to facilitate cryosectioning. Application of the storage system allows a frozen tissue specimen to be moved between storage and cryosectioning without loss of label, deformation of tissue, or thermal alterations.

Genetic Assay for Transcription Errors: Methods to Monitor Treatments or Chemicals that Increase the Error Rate of RNA synthesis

Researchers at the National Cancer Institute (NCI) developed a genetic assay for detecting transcription errors in RNA synthesis. This new assay extends the familiar concept of an Ames test which monitors DNA damage and synthesis errors to the previously inaccessible issue of RNA synthesis fidelity. The FDA requires genetic DNA focused tests for all drug approval as it assesses the in vivo mutagenic and carcinogenic potential of a drug. The new assay will open an approach to monitoring the impact of treatments on the accuracy of RNA synthesis. Errors in transcription have been hypothesized to be a component of aging and age-related diseases. The National Cancer Institute (NCI) seeks licensing partners for the genetic assay.

Microosmometer for the Study of a Wide Range of Biological, Macromolecular, Polymeric, Gel, or Other Samples

Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have discovered that changes in the osmotic pressure of tissue or hydroscopic samples having a mass of less than about one microgram and that can exert a high osmotic pressure can be measured by this method. The NICHD seeks research and co-development or licensees for a method of measuring small physical changes in small quantities of materials.

A peptide hydrogel for use in vascular anastomosis

Researchers at the National Cancer Institute (NCI), in collaboration with surgery specialists from Johns Hopkins University, developed hydrogel compositions and methods to suture blood vessels with hydrogels during microsurgery. The hydrogels particularly benefit surgeons in whole tissue transplant procedures. The NCI seeks licensing and/or co-development research collaborations for further development of this technology.