The National Cancer Institute (NCI) seek parties interested in collaborative research and/or licensing to further develop neutralizing nanobodies targeting Lassa virus as a possible treatment of Lassa virus infections.
Researchers at the National Cancer Institute developed a combination immunotherapy using Glypican-3 (GPC3)-targeted chimeric antigen receptor (CAR) T cells and a recombinant IL-7 drug for the treatment of hepatocellular carcinoma (HCC).
The Eunice Kennedy Shriver National Institute of Child Health and Human Development seeks research co-development partners and/or licensees further to develop and commercialize its novel cells and populations thereof for the treatment of oncological, bacterial, fungal and other conditions.
The National Cancer Institute (NCI) developed Chimeric Antigen Receptors (CAR)-T Cells specifically targeting the unshed portion (“stalk”) of mesothelin in mesothelioma and other tumors. The NCI seeks licensing and/or co-development research collaborations to advance the development and commercialization of these inventions for immunotherapy
Researchers at the National Cancer Institute (NCI) developed improved monospecific and bicistronic chimeric antigen receptors (CARs) targeting CD19 and CD20. Importantly, CD19 and CD20 are highly expressed in diffuse large B-cell lymphoma, acute lymphoblastic leukemia and other B-cell lymphomas. These improved CARs can be useful in treating these diseases. NCI is seeking parties interested in the co-development or licensing of this invention for immunotherapy.
The National Institute of Child Health and Human Development (NICHD) seeks licensees and/or research co-development partners for the development of cyclic peptides or peptidomimetic molecules as potential non-hormonal contraceptives for males. The cyclic peptides disrupt spermatogenesis by inhibiting the phosphorylation of GRTH/DDX25 (gonadotropin-regulated testicular helicase).
The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a method of direct identification of neoantigen-specific TCRs from tumor specimens by high-throughput single-cell sequencing.
The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for the development and commercialization of small molecule inhibitors of the Eph receptor tyrosine kinase for Eph growth-dependent solid tumors such as colorectal cancer.
Investigators at the National Cancer Institute (NCI) have discovered an adjuvanted mucosal subunit vaccine to prevent SARS-CoV-2 transmission and infection. The mucosal vaccine is composed of a novel molecular adjuvant nanoparticle that induces robust humoral and cellular immunity, as well as trained innate immunity with enhanced protection against respiratory SARS-CoV-2 exposure. The technology is available for potential licensing or collaborative research to co-develop these therapeutic targets.
Scientists at the National Cancer Institute (NCI) discovered that the cyclic peptide recifin inhibits the activity of tyrosyl-DNA phosphodiesterase 1 (TDP1), a molecular target for the sensitization of cancer cells to the topoisomerase 1 (TOP1) inhibitor camptothecin and its chemotherapeutic derivatives – such as topotecan and irinotecan. NCI seeks research co-development partners and/or licensees for the development of recifin and its analogues as new chemosensitizing agents in adjunct therapies to enhance the sensitivity of cancer cells to topotecan, irinotecan and related chemotherapeutic agents.
The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for an HLA-A*01:01 restricted human T-cell receptor recognizing the NRAS Q61K hotspot mutation for development of T cell immunotherapies against multiple cancers, including melanoma.
Researchers at the University of California, Irvine (UCI) and NCI seek licensing for a new family of far-red to near-infrared emission coumarin-based luciferins (CouLuc) with complementary mutant enzymes.
The National Institute on Aging (NIA) seeks research co-development partners and/or licensees for the development of Cα-peptide as a therapeutic for the treatment of islet amyloidosis in diabetes.
National Cancer Institute (NCI) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seek licensees for a technology involving the preparation and use of personalized tumor vaccines for cancer immunotherapy employing a therapeutic strategy called MBTA. MBTA consists of vaccinations with irradiated tumor cells pulsed with phagocytic agonists (Mannan-BAM, a polysaccharide derivative of mannan), TLR (Toll-like receptor) ligands, and agonistic Anti-CD40-monoclonal antibody.
Researchers at the National Cancer Institute have developed a glypican-1 (GPC1) chimeric antigen receptor (CAR)-T cells using short immunoglobin subclass 4 (IgG4) hinge sequences that are highly potent against GPC1-expressing tumors. NCI seeks research co-development partners and/or licensees to advance the development of GPC1-IgG4 hinge CARs for the treatment of pancreatic cancer and other GPC1-expressing tumors.
The National Cancer Institute (NCI) and the National Institute of Child Health and Human Development (NICHD) seek research co-development partners and/or licensees for an antiviral treatment that can target SARS-Cov-2 replication in Covid-19 patients.
The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for single domain antibodies targeting program death ligand 1 (PD-L1) for treatment of PD-L1-expressing cancers.
The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a method to identify T cells with preferred phenotypes for increased response from adoptive immunotherapy.
Researchers at the NCI seek licensing and/or co-development research collaborations for an anti-viral polypeptide, Griffithsin, and its antiviral use against Hepatitis C, Severe Acute Respiratory Syndrome (SARS), H5N1, or Ebola.
