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Chimeric antigen receptor (CAR) T cells that specifically target Glypican 2 (GPC2) are strong therapeutic candidates for patients with neuroblastoma and other GPC2-expressing cancers. The inventors at the National Cancer Institute (NCI) have developed a potent anti-GPC2 (CT3) CAR containing CD28 hinge and transmembrane domains (CT3.28H.BBζ) that is available for licensing and co-development.

The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a collection of T-cell receptors (TCRs) that specifically target CDKN2A mutations. CDKN2A mutations are present in a myriad of cancers. Therefore, these TCRs may be used for engineering TCR-based therapies with therapeutic potential for a broad cancer patient population.

Scientists at the National Cancer Institute (NCI) isolated a panel of single domain antibodies (known as ‘nanobodies’), targeting the S2 subunit of the spike protein of SARS-CoV-2 virus. These nanobodies bind to a highly conserved region in the S2 subunit of the spike protein, suggesting the potential to treat current and future SARS-CoV infections. The NCI seeks parties interested in collaborative research and/or licensing to further develop these nanobodies as a possible treatment of COVID-19 infections.

The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a combination immunotherapy approach of neoantigen-specific T cells administered alongside a vaccine targeting the same neoantigen for the treatment of cancer. This approach has been shown to have synergistic effect compared to the vaccine and/or T cell therapy approach alone.

The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a series of PIM Kinase targeting PROTACS.

Scientists at the National Cancer Institute (NCI) developed a potent chimeric antigen receptor (CAR) targeting glypican-3 (GPC3). GPC3 is a cell surface proteoglycan preferentially expressed on Hepatocellular Carcinoma (HCC). The specific HN3 nanobody-IgG4H-CD28TM CAR included in this invention was much more potent both in in vitro cell models and in vivo mouse models. The NCI seeks licensing and/or co-development research collaborations for further development of the anti-GPC3 CAR to treat liver cancer.

The National Cancer Institute (NCI) seek parties interested in collaborative research and/or licensing to further develop neutralizing nanobodies targeting Lassa virus as a possible treatment of Lassa virus infections.

Researchers at the National Cancer Institute developed a combination immunotherapy using Glypican-3 (GPC3)-targeted chimeric antigen receptor (CAR) T cells and a recombinant IL-7 drug for the treatment of hepatocellular carcinoma (HCC).

The Eunice Kennedy Shriver National Institute of Child Health and Human Development seeks research co-development partners and/or licensees further to develop and commercialize its novel cells and populations thereof for the treatment of oncological, bacterial, fungal and other conditions.