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Non-Invasive In Vivo MRI Method to Image Salient Features of Axons and Nerves

Scientists from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) have developed a novel diffusion Magnetic Resonance Imaging (MRI) experimental and modeling framework to measure new and useful microanatomical features of white matter (and gray matter), which are closely related to the function of the central nervous system (CNS) or peripheral nervous system (PNS). This invention is available for licensing or co-development partners.

A Novel Transgenic Zebrafish Line Reporting Dynamic Epigenetic Changes

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks licensees for a novel “EpiTag” epigenetic reporter transgenic zebrafish line that provides a versatile and powerful whole-animal platform for visualizing and assessing the effects of mutants, experimental treatments, or chemical compounds targeting epigenetic regulation as well as studying epigenetic regulation of global- or tissue-specific gene expression during development.

Autophagy Modulators For Use in Treating Cancer

Investigators from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) have identified five autophagy-inhibiting compounds (WX8 family) through a high-throughput screening. The NICHD seeks licensees and/or co-development partners for methods to treat cancer by administering these autophagy-inhibiting compounds.

Composite Gels and Methods of their Use in Tissue Repair, Drug Delivery, and as Implants

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks research partners, co-development partners, and/or licensees for hydrogels that can be used in tissue repair. Gels typically exhibit a decrease in mechanical strength (e.g., elastic modulus) upon swelling of the particles. The gels of this technology, however, exhibit an increase in mechanical strength upon swelling. The gels are comprised of a crosslinked polymer matrix dispersed in a crosslinked polymer matrix.

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