The National Cancer Institute (NCI) seeks licensees for an SLC46A3 knockout mouse line. SLC46A3 is a solute carrier of the Major Facilitator Superfamily (MFS) and is thought to have roles in multiple diseases including nonalcoholic fatty liver disease, liver cancer and obesity.
Researchers at the National Cancer Institute (NCI) have developed a bioluminescent MB49-luciferase bladder cancer cell line that can be used in preclinical studies to evaluate anti-cancer agents in bladder cancer. NCI seeks parties to non-exclusively license this research material.
The National Cancer Institute (NCI) seeks research co-development and/or potential licensees for oxynitidine derivatives as new topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors for treating cancer. These TOP1 and TDP1 inhibitors administered in combination display increased anti-tumor potency.
Researchers at the National Cancer Institute (NCI) developed orthotopic allograft models for pancreatic cancer that utilize cells or tumor fragments implanted into the cancer-free pancreata of recipient immunocompetent mice. NCI seeks licensees to commercialize this invention.
Researchers at the National Cancer Institute (NCI) RNA Biology Laboratory have developed nanoparticles that can deliver an agent (i.e., therapeutic or imaging) and release the agent upon targeted photoactivation allowing for controlled temporal and localized release of the agent.
The National Institute on Aging (NIA) seeks research licensees and/or co-development partners under a Cooperative Research and Development Agreement (CRADA) to advance preclinical and clinical development of repurposed compounds to treat Alzheimer’s disease.
Researchers at the National Institute on Aging (NIA) have developed a novel strategy for rendering weakly or non-immunogenic, shared (between self and tumor) antigens immunogenic, or able to produce an immune response. Further, they have created therapeutic polypeptides comprising tumor-associated embryonic antigens and chemoattractant ligands. Cancers targeted by these developments include breast, renal, lung, ovarian, and hematological cancers.
Prevention and control of human immunodeficiency virus (HIV) infections require a vaccine providing long-lasting protection. The most promising vaccine up to date consists of a regimen of immunization with genetically engineered HIV proteins, including the surface glycoprotein gp120, with a resulting efficacy of ~30%. Recent evidence indicates antibodies produced against variable envelope region 2 (V2) of gp120 in primates are associated with higher levels of protection, while antibodies produced against variable envelope region 1 (V1) have an opposite and interfering effect. Researchers at the National Cancer Institute (NCI) and New York University (NYU) have developed V1-deleted gp120 immunogens using Simian immunodeficiency virus (SIV), and observed an increase in antibodies against V2 in macaques upon immunization. NCI is seeking parties interested in co-developing and/or licensing V1-deleted gp120 immunogens for their use in an improved HIV vaccine.
The marginal distribution constrained optimization (MADCO) methodology is disclosed wherein a 2D (or higher-dimensional) spectrum is estimated from initial 1D marginal distribution data. These 1D marginal distributions are used as constraints in the reconstruction of the 2D spectra. MADCO accelerates and improves the reconstruction of multidimensional NMR relaxation/diffusion spectra, making it suitable for MRI applications on a voxel-by-voxel basis by vastly reducing the amount of data acquired and data necessary for creating MRI images.
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks licenses and/or co-development partners for methods of treating cancer by administering PIKFYVE inhibitors and P38 MAP kinase inhibitors.
Researchers at the National Institutes on Aging (NIA) seek research co-development or licensees for novel compounds and pharmaceutical formulations to treat autoimmune disorder and inflammation. Other potential indications for these compounds include pain, itching, and/or skin disorders.
Researchers at the National Cancer Institute (NCI) seek research co-development or licenses for a method of stimulating an immune response in a human at risk for infection by, or already infected with, an HIV-1 retrovirus. This method utilizes DNA vaccines to stimulate CD8+ T cell immune responses.
Researchers at the National Cancer Institute (NCI) have discovered that primary bile acids and antibiotics are a novel therapeutic for the treatment of liver cancer and liver metastases. NCI is seeking parties interested in licensing and/or co-developing primary bile acids and antibiotics that have been demonstrated in vivo to attract natural killer T (NKT) cells to the liver and inhibit tumor development.
Researchers at the National Cancer Institute (NCI) have developed a technology that provides methods of performing adoptive cell transfer (ACT), an immunotherapeutic approach for cancer treatment, by administering a heterodimeric Interleukin 15/Interleukin 15 receptor alpha (IL-15/IL-15Rα) complex (hetlL-15) in the absence of lymphodepletion, thereby eliminating any lymphodepletion-associated detrimental side effects.
The National Cancer Institute is seeking parties interested in licensing human monoclonal antibodies (mAbs) that bind to death receptor 4 ("DR4"). The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and its functional receptors, DR4 and DR5, have been recognized as promising targets for cancer treatment.
Researchers at the National Cancer Institute (NCI) seek research collaborations or licensees for a monoclonal antibody targeting CD276, also known as B7-H3, and related conjugates. The antibody and antibody drug conjugates (ADC) containing the antibody of the current invention were tested in vivo and have potential for use in cancer immunotherapy.
Researchers at the National Cancer Institute (NCI) seek research collaborations or licensees for a monoclonal antibody targeting TEM8 and related conjugates. The antibody and antibody drug conjugates (ADC) containing the antibody of the current invention were tested in vivo and have potential for use in cancer immunotherapy.