This invention pertains to a system for continuous observation of rodents in home-cage environments with the specific aim to facilitate the quantification of activity levels and behavioral patterns for mice housed in a commercial ventilated cage rack. The National Cancer Institute’s Radiation Biology Branch seeks partners interested in collaborative research to co-develop a video monitoring system for laboratory animals.
Researchers at the National Cancer Institute (NCI) seek licensing for an improved cell line called Tni-FNL which is capable of high level expression of heterologous proteins using baculovirus expression systems.
National Cancer Institute (NCI) researchers have isolated T-cell receptors (TCRs) reactive to the highly prevalent p53-Y220C and p53-R273C mutants. These TCRs can be used for a variety of therapeutic, diagnostic and research applications. NCI seeks licensing and/or co-development research collaborations for TCRs that recognize p53-Y220C and p53- R273C mutations, and methods for identifying p53 mutation-reactive T cell receptors.
Researchers at the National Institute on Drug Abuse (NIDA) have developed an apparatus that is used to image rodents while they are awake. The biological effects of agents on the rats can be imaged (via MRI for instance) in real time over a prolonged period of time.
Available for licensing is computer software for the automated generation of density maps of macromolecular structures from a series of 2D digital micrographs of frozen hydrated specimens collected using an electron microscope equipped with an ultra-cooled computerized stage.
The NCI Radiation Oncology Branch and the NHLBI Laboratory of Single Molecule Biophysics seek parties to co-develop fluorescent nanodiamonds for use as in vivo and in vitro optical tracking probes toward commercialization.
Researchers at the National Institutes of Health Clinical Center (NIHCC) and Northern Arizona University (NAU) seek licensing and/or co-development research collaborations for a wearable, pediatric, robotic exoskeleton that facilitates knee extension during walking to provide motorized movement assistance and training through the gait cycle. The Robotic Exoskeleton is specifically designed for therapy of crouch gait in children with cerebral palsy (CP). The design is a customizable human-machine interface that allows an individualized assistance protocol to help preserve and enhance muscle strength and control. Early clinical results from this intervention appear promising for a condition having few effective long-term interventions.
The NCI seeks licensees or co-development partners for this technology, which describes compositions, methods and kits for identifying, characterizing biomolecules expressed in a sample that are associated with the presence, the development, or progression of cancer.
Researchers at the National Institutes of Health Clinical Center (NIHCC) developed a technology that improves segmentation detail levels for anatomical structures in medical images through a new, deep learning approach. Difficult anatomical features, often segmented incorrectly with other image segmentation methods, are correctly segmented and identified using this novel technology, which is available for licensing or co-development.
The National Cancer Institute (NCI) seeks co-development partners and/or licensees for polymer-cast inserts for cell histology and microscopy; a system for high throughput three-dimensional (3D) cell culture and screening microscopy.
Researchers from NCI and Rudgers University developed methods of detecting abnormal cells in a sample using the spatial position of one or more genes within the nucleus of a cell, as well as a kit for detecting abnormal cells using such methods. The invention also provides methods of identifying gene markers for abnormal cells using the spatial position of one or more genes within the nucleus of a cell.
The National Cancer Institute seeks parties interested in collaborative research to co-develop diagnostic methods for detection of cancer using spatial genome organization.
The National Cancer Institute (NCI) seeks licensing partners for a novel modified insect cell line, Sf9-ET, that can quickly and efficiently determine baculovirus titers during the expression of recombinant proteins from a baculovirus-based protein expression system.