Search Technologies

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks research licensees and /or co-development partners under a Cooperative Research and Development Agreement (CRADA) to advance preclinical and clinical development of methods to treat Alzheimer Disease using Carboxypeptidase E (CPE).

Researchers at the National Cancer Institute (NCI) developed improved monospecific and bicistronic chimeric antigen receptors (CARs) targeting CD19 and CD20. Importantly, CD19 and CD20 are highly expressed in diffuse large B-cell lymphoma, acute lymphoblastic leukemia and other B-cell lymphomas. These improved CARs can be useful in treating these diseases. NCI is seeking parties interested in the co-development or licensing of this invention for immunotherapy.

Impairment of cell motility and membrane trafficking can result in enhanced cell proliferation and survival and increased migration and invasion leading to cancer. Several proteins involved in cell motility and membrane trafficking have been shown to be dysregulated in various cancers. Animal models that facilitate the study of roles of these proteins in vivo are therefore required. The National Cancer Institute (NCI) seeks licensees for Mouse Lines with Fluorescently Labelled Membrane Proteins Regulating Cellular Motility and Membrane Trafficking

Researchers at the National Cancer Institute developed a combination immunotherapy using Glypican-3 (GPC3)-targeted chimeric antigen receptor (CAR) T cells and a recombinant IL-7 drug for the treatment of hepatocellular carcinoma (HCC).

The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a series of PIM Kinase targeting PROTACS.

The National Cancer Institute (NCI) seeks licensees for a library of cell lines stably expressing common tumor-specific antigens and human leukocyte antigens (HLAs) that can be used to identify, isolate, and expand tumor-reactive T cells.

The NCI seeks parties interested in research co-development and/or licensing of TCRs targeting the BRAF V600E mutation. These TCRs are HLA-A*0301 restricted. The BRAF V600E mutation is common among cancer patients, giving the TCRs broad therapeutic potential in immunotherapy against multiple cancers.

The National Cancer Institute (NCI) seeks licensees for a mouse model of CD4+ T cell deficiency. The mice carry alleles with germline and conditional deletions of the Zbtb7b gene encoding the zinc finger transcription factor ThPOK or cKrox, essential for the development and function of CD4+ T cells.

The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for an anti-cancer combination therapy that includes administering a Toll-like receptor (TLR) 4 agonist, a TLR2/6 agonist, an immune checkpoint inhibitor, and a STING agonist for the treatment of resistant solid cancers.