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Technology TAB-2455
A3 Adenosine Receptor Agonists to Treat Chemotherapy-induced Peripheral Neuropathy
This invention claims species-independent agonists of A3AR, specifically (N)-methanocarba adenine nucleosides and related pharmaceutical compositions. The A3 adenosine receptor (A3AR) subtype has been linked with helping protect the heart from ischemia, controlling inflammation, and regulating cell proliferation. Agonists of the human A3AR subtype have been developed that are also selective for the mouse A3AR while retaining selectivity for the human receptor. This solves a problem for clinical development because animal model testing is important for pre-clinical validation of drug function. Novel agonists have been made that exhibit as much as 6000x selectivity for A3 versus A1 ...
Technology TAB-1112
Moonen, Chrit
In many instances, it is desirable to express exogenous genes only in certain tissues, and/or at will at certain times, and/or only to a certain degree. However, current gene transfer and exogenous gene expression protocols do not provide adequate means of simultaneously controlling which cells in a heterogeneous population are transformed and when, where, and to what degree the transferred genes are expressed. The invention provides methods for using local heat to control gene expression. The heat shock protein (hsp) gene promoter is recombined with a selected therapeutic gene and expressed in selected cells. Local controlled heating ...
Technology TAB-925
Contrast Agent Enhancement of Chemical Exchange Dependent Saturation Transfer (CEDST) MRI
Available for licensing is an MRI image improving system wherein at least one contrast agent is administered to a subject in amounts effective to perform chemical exchange dependent saturation transfer (CEDST) MRI analysis. Examples of contrast agents suitable for administration as exogenous contrast agents include at least one functional group bearing a proton capable of chemical exchange. Examples of these functional groups include, without limitation, amides, amines, and carboxyl, hydroxyl, and sulfhydryl groups. The contrast agent can be administered as a solid, as a dispersion or solution, such as an aqueous composition, as a mixture of two or more ...
Technology TAB-3755
Nipamovir: An Affordable, Oral Treatment for HIV Infection with a High Barrier to Resistance
This technology includes an oral treatment for HIV infection. Nipamovir is a low molecular weight mercaptobenzamide derivative that is simple to produce on kilogram scale and which can be used to lower or eliminate the infectivity of HIV. Extended treatment of Simian immunodeficiency virus (SIV)-infected macaques with Nipamovir lowers the viral load by 1 log unit, and eliminates the ability of remaining virus to infect other cells. Nipamovir shows similar antiviral activity in HIV-infected human cells. There are no toxic side-effects observed in animal studies with Nipamovir. Nipamovir is a simple small molecule that is not ...
Technology TAB-3735
Heterocyclic P2Y14 Antagonists for the Treatment of Various Conditions
The technology discloses composition of compounds that are highly selective P2Y14 receptor antagonists, with moderate affinity with insignificant antagonism of other P2Y receptors. These compounds might provide a treatment for patients for various disease conditions, including lung inflammation, kidney inflammation, asthma, diabetes, obesity, and neuropathic pain of diverse states. In vivo data using mouse lines with the receptor knocked out in specific tissues showed that P2Y14 receptor antagonists act on adipocytes to improve conditions of metabolic disorders. Though there are no P2Y14 receptor modulators in clinical use currently, selective P2Y14 receptor antagonists are sought as potential therapeutic treatments for ...
Technology TAB-4736
Treatment of the beta-globinopathies through inhibition of RIOK3 activity
Disorders of adult beta-globin synthesis, which include sickle cell disease (SCD) and beta-thalassemia, are the most common monogenic disorders in the world. While the curative potential of bone marrow transplantation has been demonstrated, this approach is limited to a small fraction of affected patients due to the requirement for an HLA-matched donor, the highly specialized approach that requires critical infrastructure, and the high cost. Scientists at the National Heart, Lung, and Blood Institute (NHLBI), have developed lentiviral vectors encoding shRNA to Rio-Kinase 3 (RIOK3) that decrease expression of RIOK3, leading to more robust fetal hemoglobin ...
Technology TAB-3834
TSLP Induces Neutrophil-mediated Killing of Methicillin-resistant Staphylococcus Aureus (MRSA)
This technology includes the use of thymic stromal lymphopoetin (TSLP) for the treatment of MRSA. Our studies show that mouse neutrophils express the TSLP receptor, TSLPR, and that TSLP protein is increased during cutaneous MRSA infection. Using in vitro MRSA whole blood killing assays, we show that TSLP acts on mouse neutrophils to enhance MRSA killing. In an in vivo MRSA intradermal ear infection, TSLPR-deficient mice exhibit increased MRSA burden compared to wild-type mice. Moreover, TSLP treatment increases cutaneous MRSA killing in wild-type mice, as intradermal TSLP treatment of wild-type mice results in significantly enhanced ...
Technology TAB-4476
This technology includes a method for performing cardiac imaging without the need for the patient to hold their breath. Free breathing pixel-wise myocardial T1 parameter mapping includes performing a free-breathing scan of a cardiac region at a plurality of varying saturation recovery times to acquire a k-space dataset; generating an image dataset based on the k-space dataset; and performing a respiratory motion correction process on the image dataset. The respiratory motion correction process comprises selecting a target image, co-registering each image in the dataset to the target image to determine a spatial alignment measurement ...
Technology TAB-4479
Methods and Systems for Automatically Determining Magnetic Field Inversion Time of a Tissue Species
This technology includes a computer-implemented method for determining magnetic field inversion time of a tissue species using a T1-mapping image, information about the region of interest, and a tissue classification algorithm. This method includes T1-mapping image comprising a plurality of T1 values within an expected range of T1 values for the tissue of interest. An image mask is created based on predetermined identification information about the tissue of interest. Next, an updated image mask is created based on a largest connected region in the image mask. The updated image mask is applied to the T1-mapping ...
Technology TAB-4484
Prior Enhanced Compressed Sensing (PRINCE-CS) Reconstruction for Dynamic 2D-radial Cardiac MRI
This technology includes a method to reduce scanning time while retaining high image quality during MRI scans. A reconstructed image is rendered from a set of MRI data by first estimating an image with an area which does not contain artifacts or has an artifact with a relatively small magnitude. Corresponding data elements in the estimated image and a trial image are processed, for instance by multiplication, to generate an intermediate data set. The intermediate data set is transformed and minimized iteratively to generate a reconstructed image that is free or substantially free of artifacts. A sparsifying transformation may ...
Technology TAB-4485
Device for Closure of Transvascular or Transcameral Access Ports
This technology includes part of transcatheter aortic valve replacement and to enable non-surgical thoracic aortic aneurysm endograft repair. The invention enables a completely new way to access the arterial circulation to allow introduction of large devices, such as transcatheter aortic valve replacement, percutaneous left ventricular assist devices, and thoracic aortic endografts. It also can be used in most labeled and off-label applications of Amplatzer (AGA Medical, St Jude) nitinol occluder devices to occlude intracardiac holes and to allow non-surgical direct access to the heart. This invention has been applied, using marketed devices off-label, in 15 ...
Technology TAB-4495
A Method to Guide Protocol Development for Magnetic Resonance Thermometry
This technology includes tools to guide optimization of thermometry imaging/post-processing protocols. Proton Resonance Frequency (PRF) thermometry is a widely used Magnetic Resonance Imaging (MRI) based technique to monitor changes in tissue temperature in response to thermal therapy. The use of PRF thermometry with thermal therapy procedures is indispensable to ensure delivery of desired thermal dose to the target tissue, and to minimize unintended damage to the normal tissue. Commercial Applications PRF thermometry is a high impact application of MRI and plays a critical role in guiding thermal therapy procedures. Our approach solves a significant problem encountered in ...
Technology TAB-4496
A Principal Component Analysis Based Multi-baseline Phase Correction Method for PRF Thermometry
This technology includes a novel Principal Component Analysis (PCA) based approach to correct motion related B0 changes in PRF thermometry. Proton Resonance Frequency (PRF) thermometry is a widely used Magnetic Resonance Imaging (MRI) based technique to monitor changes in tissue temperature in response to thermal therapy. The use of PRF thermometry with thermal therapy procedures is indispensable to ensure delivery of desired thermal dose to the target tissue, and to minimize unintended damage to the normal tissue. PRF thermometry relies on phase difference between the acquired images, and therefore motion related baseline changes in organs of interest and background ...
Technology TAB-4498
This technology includes the incorporation of a magnetic field gradient waveform (consisting of two or more pulses) between excitation and encoding to eliminate signal from moving fluid for imaging applications. Proton Resonance Frequency (PRF) thermometry is a widely used Magnetic Resonance Imaging (MRI) based technique to monitor changes in tissue temperature in response to thermal therapy. The use of PRF thermometry with thermal therapy procedures is indispensable to ensure delivery of desired thermal dose to the target tissue, and to minimize unintended damage to the normal tissue. Motion of this water due to ultrasound vibrations, convection, and circulation between ...
Technology TAB-4499
Campbell-Washburn, Adrienne (NHLBI)
This technology includes the determination of temperature dependent temporal deviations of the real from the intended gradient waveforms and k-space trajectories during MRI image acquisition, and the use of appropriate temperature dependent pre-compensations to avoid or reduce the image distortion caused by these temporal deviations on the gradient waveforms and k-space trajectories, which will improve imaging quality. The determination of the temperature dependence includes a) direct measurements of the trajectory at the temperature the system operates during the scan, and b) measurements of the trajectory at different temperatures and modelling or interpolating the trajectory at the ...
Technology TAB-4500
This technology includes an efficient lentiviral vector-based method for gene transfer into NK cells and demonstrates a stable and long-term robust expression of transgenes for the treatment of cancer. High gene transfer rates into primary cells being transduced and the ability to produce high titers of virus particles for large-scale transduction of patient cells are prerequisites for clinical trials. Lentiviral vectors can be produced in high titer and concentrated without compromising their transduction efficiency. Additionally, the described method is cheaper and simpler to apply clinically as it does not require the need for several cumbersome and ...
Technology TAB-4508
Phase Sensitive Motion Correction and T1 Mapping for Cardiovascular Magnetic Resonance Imaging
This technology includes a method of correcting the motion during T1 mapping using cardiovascular magnetic resonance imaging (MRI). Ischemic heart disease is the leading cause of death in the United States. The lack of blood supply among myocardial tissue, especially for scar regions, changes the T1 relaxation value of heart muscles. The non-invasive quantification of T1 value of myocardium (T1 mapping) is therefore of great importance for the diagnosis and treatment of cardiovascular disease. However, the accurate T1 measurement of myocardium is hard to achieve, mainly due to the inevitable respiratory and heart motion. This invention applies the ...
Technology TAB-4518
This technology includes in vitro-generated trophectoderm (TE) cells, which are ideal for modeling diseases of the placenta, drug screening, and cell-based therapies. The TE lineage which gives rise to placental cells during early human development. Derivation of definitive placental cells from human pluripotent stem cells in culture remains controversial and so far, placental cells can only be derived directly from primary placental tissue, which largely limits their access and study in the laboratory. This invention describes highly efficient TE differentiation, including cytotrophoblast and syncytiotrophoblast cells, by manipulating specific cell signaling pathways in chemically defined conditions. Commercial Applications ...
Technology TAB-4522
Background-free Imaging by Selective Modulation of Nanodiamond Fluorescence Using a Magnetic Field
This technology includes the use of nanodiamonds to achieve background-free imaging. We present several techniques to reduce or eliminate background florescence by exploiting properties of the fluorescent nanodiamonds. In particular, magnetic field modulation of the fluorescence intensity offers a simple, robust, and easily adaptable method to obtain background free imaging in a variety of imaging modalities, i.e., fluorescence microscopy and wide field fluorescence animal imaging. The product would consist of a means of modulating a magnetic field in an imaging system combined with the fluorescent nanodiamonds that are the source of the fluorescence. In principle this technique ...
Technology TAB-1281
A Mouse Model of Multiple Endocrine Neoplasia, Type I
The current invention embodies a mouse model which is heterozygous for a null allele at the Men1 locus of murine chromosome 19. Men1 has similar exon-intron organization and amino acid identity compared with its human analog MEN1, which has been implicated in the pathogenesis of multiple endocrine neoplasia, type I (MENI). This mouse model has been shown to develop features remarkably similar to those of MEN1, which include tumors of the endocrine pancreas, pituitary, and parathyroids. The model embodied in this invention appears to represent a valuable research tool for use in elucidating the role of the wild ...
Technology TAB-4526
Clonal Spodoptera Frugiperda Cell lines for Enhanced Expression
This technology includes Spodoptera frugiperda (Sf9) cells which were developed to produce recombinant adeno-associated virus. The cells maintain a copy of the vector genome and for production, require infection with a single baculovirus that expresses either structural and nonstructural proteins to produce rAAV, or the non-structural (Rep) proteins to produce ceDNA. Commercial Applications Spodoptera frugiperda (Sf9) cells were developed to produce recombinant adeno-associated virus. This technology can be used for the large-scale production of recombinant adeno-associated virus (rAAV), a critical component in gene therapy, by employing Spodoptera frugiperda (Sf9) cells for efficient and controlled ...
Technology TAB-4529
Prazoles as Potential Broad Spectrum Anti-viral Agents
The technology described involves the use of a compound called prazole as an anti-viral agent specifically targeting HIV-1. It was found that prazole binds to a protein called Tsg101, which is crucial for the virus's life cycle. This binding disrupts the normal interaction of Tsg101 with another protein, ubiquitin, thereby inhibiting the release of HIV-1 particles from infected cells. Additionally, the interference caused by prazole leads to the degradation of the viral protein Gag within host cells. Remarkably, any viral particles that do manage to get released in the presence of the drug are rendered ...
Technology TAB-4531
Electronic Fringe Scanning for the Improvement of Medical Imaging Technology
Wen, Han (NHLBI)
This technology includes an electronic method for fringe scanning in grating-based phase-contrast imaging, which enhances x-ray phase-contrast imaging. Traditional methods use high-density gratings and require fine grating fringes, finer than the detector's resolution, necessitating fringe scanning to obtain phase-contrast information. This process typically involves complex and precise movements of a grating for each image, challenging in applications like medical computed tomography that demand rapid gantry rotation and acquisition of numerous projection images in less than a second. The innovation of this technology lies in its ability to perform electronic fringe scanning without ...
Technology TAB-4532
Immunogens, Compositions, and Methods for the Treatment of Dyslipidemia
Remaley, Alan (NHLBI)
This technology includes a novel vaccine for forming autoantibodies against apoC-III, a plasma enzyme that inhibits lipolysis. The vaccine can possibly be used to treat patients with high triglycerides and are at risk for pancreatitis and cardiovascular disease. This disclosure describes an ApoC3 immunogen that includes an antigenicApoC3 peptide linked to a bacteriophage virus-like-particle (VLP) immunogenic carrier. Commercial Applications This vaccine has significant potential for further development as a potential therapeutic for hypertriglyceridemia. Competitive Advantages This technology for inducing autoantibodies against endogenous ApoC3 using peptides conjugated to virus-like-particles (VLPs) is completely novel and if ...
Technology TAB-4542
This technology includes a new reagent, termed bivalent Tn5 complex, and applied it to mapping genome-wide enhancer-promoter interactions to be utilized for disease diagnostics. Chromatin structure is critical for regulating transcription in normal development and disease states. In particular, the interaction between enhancers and promotes are essential for the temporospatial control of gene expression. Commercial Applications Reagents for performing this assay could be developed and commercialized Competitive Advantages The reagent and method can be applied to mapping genome-wide enhancer-promoter interactions, which are predictive of gene expression and could provide diagnostic information for diseases. Technology ID ...