Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have discovered a new microosmometer that allows for the quantification of minor changes in the swelling properties of different materials (including tissue specimens) using microgram amounts of sample. Varying the vapor pressure in the environmental chamber of the device induces controlled changes in the osmotic pressure of the specimen on the surface of a flat quartz crystal microbalance. Variation in the swelling degree is measured with high sensitivity and reliability by monitoring the change in resonance frequency of the quartz crystal oscillator. The device requires less than one microgram of sample, and possesses an extremely fast response time. The device is well-suited to the study of a wide range of biological, macromolecular, polymeric, gel, or other samples.
- Measuring hydration characteristics in tissue and other samples
- Measuring hydration isotherms in micro-gram quantities of samples
- Wide areas of application in material science, polymer science, processing, food packaging, adhesives, paint manufacture, etc.
- Requirement of 1 microgram allows probing local osmotic properties of small samples
- Rapid equilibration permits fast sample analysis
- Non-destructive evaluation possible
Ferenc Horkay ((NICHD)), Peter Basser ((NICHD)), Adam Berman ((NICHD))
- U.S. Patent Issued: U.S. Patent Number , Issued 03 Jun 2008
- U.S. Patent Filed: U.S. Patent Application Number , Filed 07 Aug 2002
- U.S. Patent Filed: U.S. Patent Application Number , Filed 07 Aug 2003