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Assay for Arf GTP-binding Proteins

Summary
The National Cancer Institute's Laboratory of Cellular and Molecular Biology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize an antibody-based proteomics assay.
NIH Reference Number
E-198-2010
Product Type
Keywords
  • Diagnostics
  • biomarker
  • proteomics
  • Arf
Collaboration Opportunity
This invention is available for licensing.
Contact
Description of Technology

The National Cancer Institute's Laboratory of Cellular and Molecular Biology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize an antibody-based proteomics assay. 

The worldwide laboratory research reagents market is expected to surpass $13 billion in 2010, and the field of biotechnology appears key to maintaining the market's growth. Antibodies are becoming increasingly significant, especially for targeting the diseased cells and cell compounds.

Researchers at the National Cancer Institute (NCI), NIH, have developed an antibody-based assay that measures levels of Arf GTP-binding proteins, some of which have been linked to the invasive behavior of cancer cells. The assay is robust, can be performed both on cell lysates and fixed cells, and can distinguish among specific endogenous Arf-GTP isoforms.

Potential Commercial Applications
  • Research on Arf function in physiology and cancer
  • Research on cancer invasion
  • Research on membrane traffic and actin reorganization
Competitive Advantages
  • Ability to distinguish between the specific isoforms (i.e., Arf1, Arf3, Arf4, Arf5, and Arf6)
  •  Antibodies bind preferentially to the GTP-bound form of Arf
Development Stage
Publications

Spang A, et al. Arf GAPs: gatekeepers of vesicle generation.  [PMID 20394747]

Campa F, et al. Arf GTPase-activating proteins and their potential role in cell migration and invasion. [PMID 19262159]

Patent Status
  • U.S. Patent Filed: U.S. Patent Application Number
Therapeutic Area
Updated
Thursday, July 19, 2018