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A Gene-Based Prognostic for Hepatocellular Carcinoma Patient Response to Adjuvant Transcatheter Arterial Chemoembolization

A Gene-Based Prognostic for Hepatocellular Carcinoma Patient Response to Adjuvant Transcatheter Arterial Chemoembolization

Summary
The gold standard of care for hepatocellular carcinoma patients with intermediate- to locally advanced tumors is transcatheter arterial chemoembolization (TACE), a procedure whereby the tumor is targeted both with local chemotherapy and restriction of local blood supply. NCI scientists have identified a 14-gene signature predictive of response to TACE, and NCI seeks licensees or co-development partners to develop the technology toward commercialization.
NIH Reference Number
E-101-2016
Product Type
Keywords
  • Prognostic, Hepatocellular Carcinoma, Gene-Expression Signature, Patient Stratification
Collaboration Opportunity
This invention is available for licensing and co-development.
Contact
Description of Technology

Hepatocellular Carcinoma (HCC) is one of the most common cancers worldwide with largely unfavorable outcomes due to a lack of effective treatment options for patients in the later state of disease. The gold standard of care for HCC patients with intermediate to locally advanced tumors is transcatheter arterial chemoembolization (TACE), a procedure whereby the tumor is targeted both with local chemotherapy and restriction of local blood supply. TACE procedures are often not effective however, and a need exists to identify patients that will respond to TACE.

NCI scientists have identified a 14-gene signature predictive of response to TACE. This “TACE Navigator Gene Signature Assay” based on a Nanostring platform, is useful in identifying HCC patients in advance who will respond to and have the greatest survival benefit following TACE, and can identify patients who need additional/alternative therapeutic modalities.

 

Potential Commercial Applications
  • Prognostic test for HCC patient response to TACE procedure
  • Companion diagnostic for TACE procedure
Competitive Advantages
  • First in class prognostic diagnostic for frontline therapy in highly prevalent HCC
Inventor(s)

Xin Wei Wang Ph.D. (NCI), Valerie Miller Ph.D. (NCI)

Development Stage
Patent Status
  • U.S. Provisional: U.S. Provisional Patent Application Number 62/292,789, Filed 08 Feb 2016
Therapeutic Area
Posted
Monday, October 24, 2016