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Silicone Hydrogel Support Structures that Mimic Tissue Vasculature for Cell Culturing

Summary
Photolithographic methods are used to construct mimetic silicone hydrogel pillars that have, for example, a 20:1 height to diameter ratio.
NIH Reference Number
E-070-2013
Product Type
Keywords
  • Silicone Hydrogel, Tissue Grafting, Tissue Engineering, Oxygen Diffusivity
Collaboration Opportunity
This invention is available for licensing and co-development.
Contact
Description of Technology

Researchers at the National Cancer Institute developed silicone hydrogel support structures that mimic tissue vasculature (e.g., capillary bed) with high oxygen diffusivity. Photolithographic methods are used to construct mimetic silicone hydrogel pillars that have, for example, a 20:1 height to diameter ratio. Advantageously, these mimetic silicone hydrogels diffuse oxygen from the bottom chamber to the cells cultured on the surface at near physiological rates (60 times that of water). Uses of these mimetics include 2-D screening for chemotherapeutic compounds and growth of tissue for grafting.

Potential Commercial Applications
  • Tissue engineering
  • Simulation of physiological growth conditions
Competitive Advantages
  • High oxygen diffusivity
Inventor(s)

Chandan Das (NCI), Michael Gottesman (NCI), Ashley Jaeger (CIT), Thomas Pohida (CIT), Randall Pursley (CIT), Philip Mcqueen (CIT), Nicole Morgan (NIBIB)

Development Stage
Publications

Jaeger AA, et al. [PMID 23911071]

Patent Status
  • U.S. Provisional: U.S. Provisional Patent Application Number 61/758,198
  • U.S. Provisional: U.S. Provisional Patent Application Number 61/773,064
  • U.S. Patent Filed: U.S. Patent Application Number 14/166,744
Therapeutic Area
Posted
Thursday, March 30, 2017