Researchers at the National Cancer Institute developed silicone hydrogel support structures that mimic tissue vasculature (e.g., capillary bed) with high oxygen diffusivity. Photolithographic methods are used to construct mimetic silicone hydrogel pillars that have, for example, a 20:1 height to diameter ratio. Advantageously, these mimetic silicone hydrogels diffuse oxygen from the bottom chamber to the cells cultured on the surface at near physiological rates (60 times that of water). Uses of these mimetics include 2-D screening for chemotherapeutic compounds and growth of tissue for grafting.
- Tissue engineering
- Simulation of physiological growth conditions
- High oxygen diffusivity
Jaeger AA, et al. [PMID 23911071]
- U.S. Provisional: U.S. Provisional Patent Application Number 61/758,198
- U.S. Provisional: U.S. Provisional Patent Application Number 61/773,064
- U.S. Patent Filed: U.S. Patent Application Number 14/166,744