Angiogenesis-Based Cancer Therapeutic
Vascular Endothelial Growth Factor-A (VEGF-A) is an angiogenic agent that drives blood vessel formation in solid tumors and other diseases, such as macular degeneration and diabetic retinopathy. Several therapies that target the ability of VEGF to stimulate angiogenesis have been approved. These therapies regulate VEGF-A activity by binding VEGF-A, thereby blocking VEGF-A from binding to its receptor on target cells. This technology utilizes a different approach to regulating VEGF-A activity by providing a VEGF-A protein antagonist that is produced by engineering native VEGF-A protein. The engineered VEGF-A protein disrupts heparin sulfate proteoglycan binding to the VEGF-A/VEGF receptor complex, an activity that is essential for the angiogenic properties of native VEGF-A. The antagonist has a binding affinity for both FLT-1 (VEGFR-1) and KDR/FLK-1 (VEGFR-2) that is equivalent to that of native VEGF-A and specifically antagonizes all VEGF-A-stimulated signaling events.
Competitive Advantages:
- Cost effective in terms of production
- High Specificity/Selectivity
Commercial Applications:
- Therapy for solid tumors or other diseases associated with angiogenic activity modulated by Vascular Endothelial Growth Factor-A expression.
Patents
- US
Provisional (PRV) 61/639,230
Filed on 2012-04-27
Status: Abandoned - Patent Cooperation Treaty
Patent Cooperation Treaty Combined (PCT COMB) PCT/US2013/038506
Filed on 2013-04-26
Status: Expired - Australia
National Stage 2013251375
Filed on 2013-04-26
Status: Issued - Canada
National Stage 2870769
Filed on 2013-04-26
Status: Issued - European Patent
National Stage 13720737.9
Filed on 2013-04-26
Status: Issued - US Patent 9,550,818
Filed on 2014-10-27
Status: Issued - Hong Kong
National Stage 15105159.9
Filed on 2015-05-29
Status: Issued - US Patent 10,035,833
Filed on 2017-01-20
Status: Issued - Belgium
European patent (EP) 13720737.9
Filed on 2014-11-26
Status: Issued - Switzerland
European patent (EP) 13720737.9
Filed on 2014-11-26
Status: Issued - Germany
European patent (EP) 13720737.9
Filed on 2014-11-26
Status: Issued - Denmark
European patent (EP) 13720737.9
Filed on 2014-11-26
Status: Issued - Spain
European patent (EP) 13720737.9
Filed on 2014-11-26
Status: Issued - France
European patent (EP) 13720737.9
Filed on 2014-11-26
Status: Issued - United Kingdom
European patent (EP) 13720737.9
Filed on 2014-11-26
Status: Issued - Ireland
European patent (EP) 13720737.9
Filed on 2014-11-26
Status: Issued - Italy
European patent (EP) 13720737.9
Filed on 2014-11-26
Status: Issued - Liechtenstein
European patent (EP) 13720737.9
Filed on 2014-11-26
Status: Issued - The Netherlands
European patent (EP) 13720737.9
Filed on 2014-11-26
Status: Issued - Portugal
European patent (EP) 13720737.9
Filed on 2014-11-26
Status: Issued - US Patent 11,434,268
Filed on 2018-07-31
Status: Issued
Collaborations
- Licensing
- Collaboration