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Opportunity Webinar Harnessing Anti-Cytomegalovirus Immunity for Local Immunotherapy against Solid Tumors

December 14, 2022 | 11:00 AM – 12:00 PM

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If you missed our December 14th Technology Opportunity Webinar, you can request the recording. Attendees heard from Deputy Chief of the NCI CCR Laboratory of Cellular Oncology, John Schiller, Ph.D. about a new immunotherapy method targeting solid tumors. This invention involves the injection of cytomegalovirus- (CMV) derived T cell minimal peptide epitopes into a solid tumor, disrupting the tumor microenvironment and allowing CD4+ and CD8+ T cells to kill the tumor cells and the generation of T cells to tumor-restricted antigens. The tumor antigen-agnostic nature of this approach makes it applicable across a broad range of solid tumors, regardless of origin. The results of his work show that CMV-derived peptide epitopes, delivered intratumorally into mice with chronic mouse CMV infections, act as cytotoxic and immunotherapeutic agents to promote immediate tumor control and long-term antitumor immunity. This technology can be used as a stand-alone therapy. Please reach out to Joseph.Conrad@nih.gov to request the recording, or if you have interest in learning about co-development and/or licensing opportunities for this technology.

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